The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity.
adverse outcome pathways
chemical testing
developmental neurotoxicity
endocrine-disrupting chemicals
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
30
03
2020
revised:
21
05
2020
accepted:
28
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
Identifiants
pubmed: 32492937
pii: ijms21113978
doi: 10.3390/ijms21113978
pmc: PMC7312023
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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