Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation.
Animals
Animals, Newborn
Calcium
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ metabolism
Cells, Cultured
Fructose-Bisphosphatase
/ metabolism
Gene Silencing
Hippocampus
/ cytology
Long-Term Potentiation
Membrane Potential, Mitochondrial
Mice, Inbred C57BL
Mitochondria
/ metabolism
Neurons
/ metabolism
Protein Binding
Protein Transport
Synapses
/ metabolism
astrocyte-neuron lactate shuttle
memory formation
moonlighting protein
protein–protein interaction
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
23
04
2020
revised:
27
05
2020
accepted:
28
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Long-term potentiation (LTP) is a molecular basis of memory formation. Here, we demonstrate that LTP critically depends on fructose 1,6-bisphosphatase 2 (Fbp2)-a glyconeogenic enzyme and moonlighting protein protecting mitochondria against stress. We show that LTP induction regulates Fbp2 association with neuronal mitochondria and Camk2 and that the Fbp2-Camk2 interaction correlates with Camk2 autophosphorylation. Silencing of Fbp2 expression or simultaneous inhibition and tetramerization of the enzyme with a synthetic effector mimicking the action of physiological inhibitors (NAD
Identifiants
pubmed: 32492972
pii: cells9061375
doi: 10.3390/cells9061375
pmc: PMC7349836
pii:
doi:
Substances chimiques
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Camk2a protein, mouse
EC 2.7.11.17
Fructose-Bisphosphatase
EC 3.1.3.11
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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