SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines.
Animals
Antibodies, Viral
/ adverse effects
Antibody-Dependent Enhancement
/ immunology
Betacoronavirus
/ genetics
COVID-19
COVID-19 Vaccines
Coronavirus Infections
/ epidemiology
Humans
Pandemics
/ prevention & control
Pneumonia, Viral
/ epidemiology
SARS-CoV-2
Spike Glycoprotein, Coronavirus
/ chemistry
Translational Research, Biomedical
Viral Vaccines
/ adverse effects
SARS-CoV-2
SPIKE protein
Vaccine
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
received:
22
04
2020
accepted:
28
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
17
6
2020
Statut:
epublish
Résumé
COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.
Identifiants
pubmed: 32493510
doi: 10.1186/s12967-020-02392-y
pii: 10.1186/s12967-020-02392-y
pmc: PMC7268185
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Spike Glycoprotein, Coronavirus
0
Viral Vaccines
0
spike protein, SARS-CoV-2
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
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