Gene editing to induce FOXP3 expression in human CD4

Animals Forkhead Transcription Factors / genetics Gene Editing Humans Immune Tolerance Mice Phenotype T-Lymphocytes, Regulatory

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
03 06 2020
Historique:
received: 05 07 2019
revised: 09 12 2019
accepted: 13 04 2020
entrez: 5 6 2020
pubmed: 5 6 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Thymic regulatory T cells (tT

Identifiants

DOI: 10.1126/scitranslmed.aay6422 PMID: 32493794
pubmed: 32493794
pii: 12/546/eaay6422
doi: 10.1126/scitranslmed.aay6422
pii:
doi:

Substances chimiques

FOXP3 protein, human 0
Forkhead Transcription Factors 0
Foxp3 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Yuchi Honaker (Y)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0001-7183-4916

Nicholas Hubbard (N)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0002-6322-4840

Yufei Xiang (Y)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0001-8990-9111

Logan Fisher (L)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0003-4680-1527

David Hagin (D)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0003-2702-1031

Karen Sommer (K)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0003-4370-4772

Yumei Song (Y)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0001-6758-9970

Soo Jung Yang (SJ)

Benaroya Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0002-4011-6599

Christina Lopez (C)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.

Tori Tappen (T)

Benaroya Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0002-8747-3067

Elizabeth M Dam (EM)

Benaroya Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0003-3589-2988

Iram Khan (I)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0003-4202-7108

Malika Hale (M)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
ORCID: 0000-0002-0822-7141

Jane H Buckner (JH)

Benaroya Research Institute, Seattle, WA 98101, USA.
Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Department of Immunology, University of Washington, Seattle, WA 98101, USA.
ORCID: 0000-0002-9005-1885

Andrew M Scharenberg (AM)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA. drawling@uw.edu andrewms@uw.edu.
Department of Immunology, University of Washington, Seattle, WA 98101, USA.
Department of Pediatrics, University of Washington, Seattle, WA 98101, USA.
ORCID: 0000-0002-4292-6114

Troy R Torgerson (TR)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Department of Immunology, University of Washington, Seattle, WA 98101, USA.
Department of Pediatrics, University of Washington, Seattle, WA 98101, USA.
ORCID: 0000-0003-3489-5036

David J Rawlings (DJ)

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA. drawling@uw.edu andrewms@uw.edu.
Department of Immunology, University of Washington, Seattle, WA 98101, USA.
Department of Pediatrics, University of Washington, Seattle, WA 98101, USA.
ORCID: 0000-0003-4370-4772

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Gene editing to induce FOXP3 expression in human CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Gene editing to induce FOXP3 expression in human CD4