Landscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity.
Brain
/ immunology
Brain Neoplasms
/ immunology
Female
Gene Expression
/ immunology
Humans
Male
Meningeal Neoplasms
/ immunology
Meningioma
/ immunology
Neoplasm Grading
Neutrophils
/ immunology
Skull Base
/ immunology
Skull Base Neoplasms
/ immunology
T-Lymphocytes
/ immunology
Transcriptome
/ immunology
Tumor Microenvironment
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
received:
23
01
2019
accepted:
20
04
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Modulation of tumor microenvironment is an emerging frontier for new therapeutics. However in meningiomas, the most frequent adult brain tumor, the correlation of microenvironment with tumor phenotype is scarcely studied. We applied a variety of systems biology approaches to bulk tumor transcriptomics to explore the immune environments of both skull base and convexity (hemispheric) meningiomas. We hypothesized that the more benign biology of skull base meningiomas parallels the relative composition and activity of immune cells that oppose tumor growth and/or survival. We firstly applied gene co-expression networks to tumor bulk transcriptomics from 107 meningiomas (derived from 3 independent studies) and found immune processes to be the sole biological mechanism correlated with anatomical location while correcting for tumour grade. We then derived tumor immune cell fractions from bulk transcriptomics data and examined the immune cell-cytokine interactions using a network-based approach. We demonstrate that oncolytic Gamma-Delta T cells dominate skull base meningiomas while mast cells and neutrophils, known to play a role in oncogenesis, show greater activity in convexity tumors. Our results are the first to suggest the importance of tumor microenvironment in meningioma biology in the context of anatomic location and immune landscape. These findings may help better inform surgical decision making and yield location-specific therapies through modulation of immune microenvironment.
Identifiants
pubmed: 32493984
doi: 10.1038/s41598-020-65365-7
pii: 10.1038/s41598-020-65365-7
pmc: PMC7270140
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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