Enhanced dose measurement of zinc oxide nanoparticles by radiochromic polymer dosimeter and Monte Carlo simulation.
Dosimetry
Monte carlo.
Nano particles
Radiation
ZnO
Journal
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
ISSN: 1507-1367
Titre abrégé: Rep Pract Oncol Radiother
Pays: Poland
ID NLM: 100885761
Informations de publication
Date de publication:
Historique:
received:
28
01
2020
revised:
11
03
2020
accepted:
10
04
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
5
6
2020
Statut:
ppublish
Résumé
The aim of this study is to evaluate the effects of Zinc Oxide nanoparticles on dose enhancement factor using PRESAGE dosimeter and Monte Carlo simulation. High Z materials absorb X-ray remarkably. Among Nano-science, Zinc Oxide nanoparticles are interesting semiconductors, producing reactive oxygen species when irradiated by photons. Therefore, it seems that dose enhancement originating by incorporating ZnO NPs in irradiated volume would increase the therapeutic ratio. Initially, the PRESAGE dosimeter was fabricated and calibrated. Then Zinc Oxide nanoparticles with an average particle size of about 40 nm were synthesized. At next step, various concentrations of the nanoparticles were incorporated into the PRESAGE composition and irradiated in radiation fields. Then, the mentioned processes were simulated. Practical measurements revealed that by incorporating 500, 1000 and 3000 μg ml The results of this study showed that dose enhancement increases by increasing concentration of Zinc Oxide nanoparticles. Many reasons such as photoelectric, pair production effects and even Compton scattering can cause dose enhancement for megavoltage beams.
Sections du résumé
AIM
OBJECTIVE
The aim of this study is to evaluate the effects of Zinc Oxide nanoparticles on dose enhancement factor using PRESAGE dosimeter and Monte Carlo simulation.
BACKGROUND
BACKGROUND
High Z materials absorb X-ray remarkably. Among Nano-science, Zinc Oxide nanoparticles are interesting semiconductors, producing reactive oxygen species when irradiated by photons. Therefore, it seems that dose enhancement originating by incorporating ZnO NPs in irradiated volume would increase the therapeutic ratio.
MATERIALS AND METHODS
METHODS
Initially, the PRESAGE dosimeter was fabricated and calibrated. Then Zinc Oxide nanoparticles with an average particle size of about 40 nm were synthesized. At next step, various concentrations of the nanoparticles were incorporated into the PRESAGE composition and irradiated in radiation fields. Then, the mentioned processes were simulated.
RESULTS
RESULTS
Practical measurements revealed that by incorporating 500, 1000 and 3000 μg ml
CONCLUSION
CONCLUSIONS
The results of this study showed that dose enhancement increases by increasing concentration of Zinc Oxide nanoparticles. Many reasons such as photoelectric, pair production effects and even Compton scattering can cause dose enhancement for megavoltage beams.
Identifiants
pubmed: 32494225
doi: 10.1016/j.rpor.2020.04.008
pii: S1507-1367(20)30064-X
pmc: PMC7252207
doi:
Types de publication
Journal Article
Langues
eng
Pagination
515-520Informations de copyright
© 2020 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.
Références
Food Sci Technol Int. 2010 Jun;16(3):225-32
pubmed: 21339138
Med Phys. 2008 Jan;35(1):206-15
pubmed: 18293576
ACS Nano. 2008 May;2(5):889-96
pubmed: 19206485
J Cancer Res Ther. 2017 Apr-Jun;13(2):175-185
pubmed: 28643730
Nanomedicine. 2012 May;8(4):526-36
pubmed: 21864490
Chem Res Toxicol. 2010 Apr 19;23(4):733-9
pubmed: 20155942
Apoptosis. 2012 Aug;17(8):852-70
pubmed: 22395444
Nanoscale Res Lett. 2009 Sep 16;4(12):1409-20
pubmed: 20652105
Photochem Photobiol Sci. 2010 Apr;9(4):495-509
pubmed: 20354643
Environ Sci Technol. 2007 Dec 15;41(24):8484-90
pubmed: 18200883
Phys Med Biol. 2009 Aug 21;54(16):4889-905
pubmed: 19636084