The Effect of High Dose Rate Interstitial Implant on Early and Locally Advanced Oral Cavity Cancers: Update and Long-Term Follow-Up Study.
external beam radiation therapy
high dose rate interstitial brachytherapy
oral cavity cancer
organ preservation
squamous cell carcinoma
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
5
6
2020
Statut:
epublish
Résumé
Introduction Brachytherapy, with or without external beam radiation therapy (EBRT), can be an alternative to surgery for organ preservation in early and locally advanced oral cavity cancers. This study aims to evaluate the effect of high dose rate (HDR) interstitial brachytherapy on early and locally advanced squamous cell carcinoma (SCC) of the oral cavity when used alone or as a boost to EBRT. Methods A total of 125 patients with histologically proven stage T1-3/N0-1 SCC of the oral cavity were included in the study. A total of 15 patients with stage I disease received an interstitial implant dose of 3,850 cGy at 350 cGy per fraction, two fractions a day. Another 53 patients had stage II, and 57 patients had stage III disease; these patients received EBRT of 50 Gy in 25 fractions along with an HDR brachytherapy boost of 21 Gy in seven fractions of 3 Gy per fraction twice daily. The stage III patients also received concurrent chemotherapy with injections of cisplatin (70 mg/m
Identifiants
pubmed: 32494525
doi: 10.7759/cureus.7910
pmc: PMC7263712
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e7910Informations de copyright
Copyright © 2020, Vedasoundaram et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1190-8
pubmed: 11483328
Brachytherapy. 2010 Jul-Sep;9(3):235-8
pubmed: 20116345
Brachytherapy. 2010 Jul-Sep;9(3):227-34
pubmed: 20116340
Oral Oncol. 2018 May;80:16-22
pubmed: 29706184
Int J Radiat Oncol Biol Phys. 1987 Apr;13(4):511-6
pubmed: 3558042
N Engl J Med. 2004 May 6;350(19):1937-44
pubmed: 15128893
J Radiat Res. 2013 Jan;54(1):1-17
pubmed: 23179377
Laryngoscope. 1999 Dec;109(12):1967-73
pubmed: 10591356
N Engl J Med. 2004 May 6;350(19):1945-52
pubmed: 15128894
Brachytherapy. 2009 Apr-Jun;8(2):248-254
pubmed: 19230791
Cancer. 1985 Mar 1;55(5):941-8
pubmed: 3967201
Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2567-2572
pubmed: 28321535
Springerplus. 2014 Oct 09;3:590
pubmed: 25332889
JAMA Otolaryngol Head Neck Surg. 2017 Jul 1;143(7):691-699
pubmed: 28426848
Int J Radiat Oncol Biol Phys. 1990 Dec;19(6):1369-76
pubmed: 2262360