A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis.
Peru
case–control study
cutaneous leishmaniasis
intestinal helminthiasis
treatment failure
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
17
01
2020
accepted:
08
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
5
6
2020
Statut:
epublish
Résumé
Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb An unmatched case-control study was done in 4 CL treatment sites in Peru in 2012-2015. Cases were CL patients with Sb There were 94 case and 122 control subjects. Overall, infectious and noninfectious comorbidities were frequent both among cases (64%) and controls (71%). The adjusted odds ratio (OR) for the association between any intestinal helminth infection and CL treatment failure was 0.65 (95% confidence interval [CI], 0.30-1.38), and the adjusted OR for the association between strongyloidiasis and CL treatment failure was 0.34 (95% CI, 0.11-0.92). In the Peruvian setting, high Sb
Sections du résumé
BACKGROUND
BACKGROUND
Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb
METHODS
METHODS
An unmatched case-control study was done in 4 CL treatment sites in Peru in 2012-2015. Cases were CL patients with Sb
RESULTS
RESULTS
There were 94 case and 122 control subjects. Overall, infectious and noninfectious comorbidities were frequent both among cases (64%) and controls (71%). The adjusted odds ratio (OR) for the association between any intestinal helminth infection and CL treatment failure was 0.65 (95% confidence interval [CI], 0.30-1.38), and the adjusted OR for the association between strongyloidiasis and CL treatment failure was 0.34 (95% CI, 0.11-0.92).
CONCLUSIONS
CONCLUSIONS
In the Peruvian setting, high Sb
Identifiants
pubmed: 32494582
doi: 10.1093/ofid/ofaa155
pii: ofaa155
pmc: PMC7252286
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofaa155Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
Clin Microbiol Rev. 2012 Oct;25(4):585-608
pubmed: 23034321
Parasit Vectors. 2013 Mar 22;6:79
pubmed: 23522098
Clin Infect Dis. 2008 Jan 15;46(2):223-31
pubmed: 18171254
PLoS One. 2016 Feb 19;11(2):e0149697
pubmed: 26894430
Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1453-61
pubmed: 22083340
PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0006141
pubmed: 29329311
J Glob Infect Dis. 2010 Sep;2(3):248-57
pubmed: 20927287
Trends Immunol. 2016 Sep;37(9):597-607
pubmed: 27501916
Infect Immun. 2009 May;77(5):2022-9
pubmed: 19237520
PLoS Negl Trop Dis. 2019 Mar 21;13(3):e0007265
pubmed: 30897083
J Clin Microbiol. 2013 Jun;51(6):1826-33
pubmed: 23554201
Wkly Epidemiol Rec. ;92(38):557-65
pubmed: 28945057
Parasite Immunol. 2002 Jul;24(7):339-45
pubmed: 12164819
J Clin Microbiol. 2012 Feb;50(2):495-8
pubmed: 22116151
J Infect Dis. 2007 Jun 15;195(12):1846-51
pubmed: 17492601
BMJ. 2007 Oct 20;335(7624):806-8
pubmed: 17947786
Infect Immun. 2002 Feb;70(2):427-33
pubmed: 11796567
J Infect Dis. 2016 Jan 1;213(1):112-21
pubmed: 26123565
J Infect Dis. 2016 Jan 1;213(1):105-11
pubmed: 26123564
Acta Trop. 2008 Jan;105(1):1-9
pubmed: 17884002
Comp Immunol Microbiol Infect Dis. 2004 Sep;27(5):305-18
pubmed: 15225981
Am J Trop Med Hyg. 2011 Apr;84(4):551-5
pubmed: 21460008
PLoS One. 2012;7(5):e35671
pubmed: 22693548
PLoS One. 2012;7(8):e42901
pubmed: 22952620
J Infect Dis. 2007 Jan 1;195(1):142-8
pubmed: 17152018
Clin Infect Dis. 1996 Oct;23(4):836-7
pubmed: 8909860
Clin Infect Dis. 2003 Sep 1;37(5):628-33
pubmed: 12942392
Exp Parasitol. 2013 Jul;134(3):281-9
pubmed: 23562705
Parasite Immunol. 2011 Apr;33(4):226-35
pubmed: 21204851
Lancet. 2018 Sep 15;392(10151):951-970
pubmed: 30126638
Acta Trop. 2016 Feb;154:42-9
pubmed: 26519200