Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
04 2020
Historique:
received: 07 08 2019
accepted: 03 02 2020
entrez: 5 6 2020
pubmed: 5 6 2020
medline: 5 6 2020
Statut: epublish

Résumé

Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST application in the primary visual cortex (V1) improves visual discrimination in freely moving mice and enhances orientation selectivity of V1 neurons. We also found that SST reduced excitatory synaptic transmission to parvalbumin-positive (PV

Identifiants

pubmed: 32494634
doi: 10.1126/sciadv.aaz0517
pii: aaz0517
pmc: PMC7176413
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaaz0517

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

You-Hyang Song (YH)

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Yang-Sun Hwang (YS)

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Kwansoo Kim (K)

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Hyoung-Ro Lee (HR)

Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Jae-Hyun Kim (JH)

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Catherine Maclachlan (C)

Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Anaelle Dubois (A)

Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Min Whan Jung (MW)

Center for Synaptic Brain Dysfunctions, Institute for Basic Science and Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Carl C H Petersen (CCH)

Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Graham Knott (G)

Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Suk-Ho Lee (SH)

Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Seung-Hee Lee (SH)

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Classifications MeSH