CRISPR-based gene editing enables


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
05 2020
Historique:
received: 08 08 2019
accepted: 20 02 2020
entrez: 5 6 2020
pubmed: 5 6 2020
medline: 9 4 2022
Statut: epublish

Résumé

The prototypical genetic autoimmune disease is immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, a severe pediatric disease with limited treatment options. IPEX syndrome is caused by mutations in the forkhead box protein 3 (

Identifiants

pubmed: 32494707
doi: 10.1126/sciadv.aaz0571
pii: aaz0571
pmc: PMC7202871
doi:

Substances chimiques

FOXP3 protein, human 0
Forkhead Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaaz0571

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123896
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL140081
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA170721
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

M Goodwin (M)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

E Lee (E)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine, Stanford, CA, USA.

U Lakshmanan (U)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

S Shipp (S)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

L Froessl (L)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

F Barzaghi (F)

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

L Passerini (L)

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

M Narula (M)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

A Sheikali (A)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

C M Lee (CM)

APC Microbiome Ireland, University College Cork, Cork, Ireland.

G Bao (G)

Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX, USA.

C S Bauer (CS)

Phoenix Children's Hospital, Phoenix, AZ, USA.

H K Miller (HK)

Phoenix Children's Hospital, Phoenix, AZ, USA.

M Garcia-Lloret (M)

Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.

M J Butte (MJ)

Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.

A Bertaina (A)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

A Shah (A)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

M Pavel-Dinu (M)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

A Hendel (A)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Ramat-Gan 52900, Israel.

M Porteus (M)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine, Stanford, CA, USA.

M G Roncarolo (MG)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine, Stanford, CA, USA.

R Bacchetta (R)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

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Classifications MeSH