Impact of passive heat acclimation on markers of kidney function during heat stress.


Journal

Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940

Informations de publication

Date de publication:
01 2021
Historique:
received: 10 04 2020
accepted: 01 06 2020
pubmed: 5 6 2020
medline: 22 2 2022
entrez: 5 6 2020
Statut: ppublish

Résumé

What is the central question of this study? Does passive heat acclimation alter glomerular filtration rate and urine-concentrating ability in response to passive heat stress? What is the main finding and its importance? Glomerular filtration rate remained unchanged after passive heat stress, and heat acclimation did not alter this response. However, heat acclimation mitigated the reduction in urine-concentrating ability and reduced the incidence of albuminuria in young healthy adults after passive heat stress. Collectively, these results suggest that passive heat acclimation might improve structural integrity and reduce glomerular permeability during passive heat stress. Little is known about the effect of heat acclimation on kidney function during heat stress. The purpose of this study was to determine the impact of passive heat stress and subsequent passive heat acclimation on markers of kidney function. Twelve healthy adults (seven men and five women; 26 ± 5 years of age; 72.7 ± 8.6 kg; 172.4 ± 7.5 cm) underwent passive heat stress before and after a 7 day controlled hyperthermia heat acclimation protocol. The impact of passive heat exposure on urine and serum markers of kidney function was evaluated before and after heat acclimation. Glomerular filtration rate, determined from creatinine clearance, was unchanged with passive heat stress before (pre, 133 ± 41 ml min

Identifiants

pubmed: 32495481
doi: 10.1113/EP088637
doi:

Substances chimiques

Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

269-281

Informations de copyright

© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.

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Auteurs

Nicholas Ravanelli (N)

Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, QC, Canada.
Research Centre, Montreal Heart Institute, Montreal, QC, Canada.
Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

Hadiatou Barry (H)

Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, QC, Canada.
Research Centre, Montreal Heart Institute, Montreal, QC, Canada.
Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

Zachary J Schlader (ZJ)

Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, USA.

Daniel Gagnon (D)

Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, QC, Canada.
Research Centre, Montreal Heart Institute, Montreal, QC, Canada.
Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

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