LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models.
NAFLD
atherosclerosis
liver X receptors
nuclear receptors
obesity
phosphorylation
transcription
Journal
Endocrinology
ISSN: 1945-7170
Titre abrégé: Endocrinology
Pays: United States
ID NLM: 0375040
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
21
02
2020
accepted:
29
05
2020
pubmed:
5
6
2020
medline:
15
12
2020
entrez:
5
6
2020
Statut:
ppublish
Résumé
Posttranslational modifications, such as phosphorylation, are a powerful means by which the activity and function of nuclear receptors such as LXRα can be altered. However, despite the established importance of nuclear receptors in maintaining metabolic homeostasis, our understanding of how phosphorylation affects metabolic diseases is limited. The physiological consequences of LXRα phosphorylation have, until recently, been studied only in vitro or nonspecifically in animal models by pharmacologically or genetically altering the enzymes enhancing or inhibiting these modifications. Here we review recent reports on the physiological consequences of modifying LXRα phosphorylation at serine 196 (S196) in cardiometabolic disease, including nonalcoholic fatty liver disease, atherosclerosis, and obesity. A unifying theme from these studies is that LXRα S196 phosphorylation rewires the LXR-modulated transcriptome, which in turn alters physiological response to environmental signals, and that this is largely distinct from the LXR-ligand-dependent action.
Identifiants
pubmed: 32496563
pii: 5851404
doi: 10.1210/endocr/bqaa089
pmc: PMC7324054
pii:
doi:
Substances chimiques
Liver X Receptors
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL117226
Pays : United States
Organisme : British Heart Foundation
ID : PG/16/87/32492
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : P01 HL131481
Pays : United States
Organisme : British Heart Foundation
ID : PG/13/10/30000
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL084312
Pays : United States
Organisme : Medical Research Council
ID : G0801278
Pays : United Kingdom
Informations de copyright
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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