Overactive bladder and sleep disturbance have a significant effect on indoor falls: Results from the community health survey in Japan.
Accidental Falls
/ statistics & numerical data
Age Factors
Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Frailty
/ complications
Health Surveys
Humans
Independent Living
/ statistics & numerical data
Japan
/ epidemiology
Logistic Models
Male
Middle Aged
Risk Factors
Sex Factors
Sleep Wake Disorders
/ complications
Urinary Bladder, Overactive
/ complications
lower urinary tract symptoms
nocturia
overactive bladder
sleep: fall
Journal
Lower urinary tract symptoms
ISSN: 1757-5672
Titre abrégé: Low Urin Tract Symptoms
Pays: Australia
ID NLM: 101506777
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
20
03
2020
revised:
22
04
2020
accepted:
12
05
2020
pubmed:
5
6
2020
medline:
7
10
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older. We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in Hirosaki, Japan. OAB symptoms and sleep disturbance were assessed using the Overactive Bladder Symptom Score (OABSS) and the Pittsburgh Sleep Quality Index (PSQI). Indoor fall events (falls or near-falls) within 1 year were evaluated. Frailty was evaluated by the frailty discriminant score. We investigated the association of OAB symptoms with sleep disturbance, frailty, and indoor fall events. Multivariate logistic regression analysis was performed to investigate the effect of OAB symptoms on fall events controlling for confounding factors such as age, gender, comorbidity, frailty, and sleep disturbance. The median age was 64. We observed OABSS ≥6 in 98 participants (14%), nocturia ≥2 in 445 (62%), urgency score ≥3 in 80 (11%), urge incontinence score ≥3 in 36 (5.0%), PSQI ≥6 in 153 (21%), frailty in 169 (23%), and indoor fall events in 251 (35%). Older age, diabetes, OABSS, nocturia, urgency, urge incontinence, and the PSQI were significantly associated with indoor fall events. Multivariate logistic regression analyses showed that OAB symptoms and sleep disturbance were significantly associated with fall events. The effect of OAB symptoms and sleep disturbance on indoor fall events was significant. The causal relationship between OAB and falls needs further study.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-63Subventions
Organisme : Center of Innovation Program
ID : JPMJCE1302
Organisme : Japan Society for the Promotion of Science
ID : 15H02563
Organisme : Japan Society for the Promotion of Science
ID : 17K11119
Organisme : Japan Society for the Promotion of Science
ID : 19H05556
Organisme : Hirosaki University
Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
Références
Ma T, Shi G, Zhu Y, et al. Sleep disturbances and risk of falls in an old Chinese population-Rugao longevity and ageing study. Arch Gerontol Geriatr. 2017;73:8-14.
Takada S, Yamamoto Y, Shimizu S, et al. Association between subjective sleep quality and future risk of falls in older people: results from LOHAS. J Gerontol A Biol Sci Med Sci. 2018;73:1205-1211.
Cheng MH, Chang SF. Frailty as a risk factor for falls among community dwelling people: evidence from a meta-analysis. J Nurs Scholarsh. 2017;49:529-536.
Hwang TY, Kim SK, Kim KH, Kim JY. Association between lower urinary tract symptoms and falls in adults males: based on the Korean community health survey. Asia Pac J Public Health. 2019;31:643-651.
Nakagawa H, Niu K, Hozawa A, et al. Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. J Urol. 2010;184:1413-1418.
Karlsson MK, Magnusson H, von Schewelov T, Rosengren BE. Prevention of falls in the elderly-a review. Osteoporos Int. 2013;24:747-762.
Momota M, Hatakeyama S, Soma O, Hamano I, et al. Frailty is a predictor of moderate to severe pain after robot-assisted laparoscopic prostatectomy: a case-control study (FRAP study). BJUI Compass. 2020;2.
Momota M, Hatakeyama S, Soma O, et al. Geriatric 8 screening of frailty in patients with prostate cancer. Int J Urol. 2020;27 https://doi.org/10.1111/iju.14256.
Okita K, Hatakeyama S, Momota M, Soma O, Hamano I, Tanaka T. Frailty is significantly associated with the type of urinary diversion in patients with muscle-invasive bladder cancer. Int J Urol. 2020;27 https://doi.org/10.1111/iju.14263.
Sebastianelli A, Russo GI, Kaplan SA, et al. Systematic review and meta-analysis on the efficacy and tolerability of mirabegron for the treatment of storage lower urinary tract symptoms/overactive bladder: comparison with placebo and tolterodine. Int J Urol. 2018;25:196-205.
Yoshida M, Kato D, Nishimura T, van Schyndle J, Uno S, Kimura T. Anticholinergic burden in the Japanese elderly population: use of antimuscarinic medications for overactive bladder patients. Int J Urol. 2018;25:855-862.
Soma O, Hatakeyama S, Imai A, et al. Relationship between frailty and lower urinary tract symptoms among community-dwelling adults. Low Urin Tract Sympt. 2020;12:128-136.
Kido K, Hatakeyama S, Imai A, et al. Sleep disturbance has a higher impact on general and mental quality of life reduction than Nocturia: results from the community health survey in Japan. Eur Urol Focus. 2019;5:1120-1126.
Yamanishi Y, Yamanishi T, Tajima H, Ikeda S. Mirabegron or tolterodine for the treatment of overactive bladder in Japan: which drug is more cost-effective as the first-line treatment? Int J Urol. 2018;25:863-870.
Yokoyama O, Ozeki A, Suzuki N, Murakami M. Early improvement of storage or voiding symptoms by tadalafil predicts treatment outcomes in patients with lower urinary tract symptoms from benign prostatic hyperplasia. Int J Urol. 2018;25:240-245.
Ninomiya S, Naito K, Nakanishi K, Okayama H. Prevalence and risk factors of urinary incontinence and overactive bladder in Japanese women. Low Urin Tract Sympt. 2018;10:308-314.
Shin JH, Choo MS. Effectiveness and persistence of mirabegron as a first-line treatment in patients with overactive bladder in real-life practice. Low Urin Tract Sympt. 2019;11:151-157.
Yoshida M, Nozawa Y, Kato D, Tabuchi H, Kuroishi K. Safety and effectiveness of mirabegron in patients with overactive bladder aged >/=75 years: analysis of a Japanese post-marketing study. Low Urin Tract Sympt. 2019;11:30-38.
Matsumoto T, Hatakeyama S, Narita T, Yoneyama T, Hashimoto Y, Ohyama C. Evaluating the effects of switching from dutasteride to tadalafil in benign prostatic hyperplasia patients with lower urinary tract symptoms: a randomized, open-label, multicenter study. Int J Urol. 2019;26:522-523.
Okamoto T, Hatakeyama S, Imai A, et al. The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan. World J Urol. 2020.https://doi.org/10.1007/s00345-020-03167-2.
Szabo SM, Gooch KL, Walker DR, Johnston KM, Wagg AS. The association between overactive bladder and falls and fractures: a systematic review. Adv Ther. 2018;35:1831-1841.
Fukunaga A, Kawaguchi T, Funada S, et al. Sleep disturbance worsens lower urinary tract symptoms: the Nagahama study. J Urol. 2019;202:354.
Chen LC, Kuo HC. Pathophysiology of refractory overactive bladder. Low Urin Tract Sympt. 2019;11:177-181.
Matsumoto T, Hatakeyama S, Imai A, et al. Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan. BJU Int. 2019;123:877-884.
Soma O, Hatakeyama S, Okamoto T, et al. Multicenter prospective study validating the efficacy of a quantitative assessment tool for frailty in patients with urological cancers. Med Oncol. 2019;36:88.
Okamoto T, Hatakeyama S, Imai A, et al. The relationship between gait function and erectile dysfunction: results from a community-based cross-sectional study in Japan. J Sex Med. 2019;16:1922-1929.
Okita K, Hatakeyama S, Imai A, et al. STone episode prediction: development and validation of the prediction nomogram for urolithiasis. Int J Urol. 2020;27:344-349.
Okamoto T, Hatakeyama S, Imai A, et al. The association between gut microbiome and erectile dysfunction: a community-based cross-sectional study in Japan. Int Urol Nephrol. 2020. https://doi.org/10.1007/s11255-020-02443-9.
Soma O, Hatakeyama S, Okamoto T, et al. Clinical implication of a quantitative frailty assessment tool for prognosis in patients with urological cancers. Oncotarget. 2018;9:17396-17405.
Rosenblatt NJ, Marone J, Grabiner MD. Preventing trip-related falls by community-dwelling adults: a prospective study. J Am Geriatr Soc. 2013;61:1629-1631.
Nouredanesh M, Gordt K, Schwenk M, Tung J. Automated detection of multidirectional compensatory balance reactions: a step towards tracking naturally-occurring near-falls. IEEE Trans Neural Syst Rehabil Eng. 2020;28:478-487.
Grabiner MD, Bareither ML, Gatts S, Marone J, Troy KL. Task-specific training reduces trip-related fall risk in women. Med Sci Sports Exerc. 2012;44:2410-2414.
Kruschke C, Butcher HK. Evidence-based practice guideline: fall prevention for older adults. J Gerontol Nurs. 2017;43:15-21.
Lee WJ, Peng LN, Liang CK, Chiou ST, Chen LK. Long sleep duration, independent of frailty and chronic inflammation, was associated with higher mortality: a national population-based study. Geriatr Gerontol Int. 2017;17:1481-1487.