Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate.
Adolescent
Age Factors
Body Composition
Body Mass Index
Body Weight
Case-Control Studies
Child
Electric Impedance
Female
Gonadotropin-Releasing Hormone
/ analogs & derivatives
Humans
Insulin
/ blood
Insulin Resistance
Leuprolide
/ therapeutic use
Puberty, Precocious
/ drug therapy
Telomere
/ metabolism
Telomere Homeostasis
Young Adult
GnRH analog
Idiopathic central precocious puberty
leuprolide acetate
obesity
telomere length
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
ISSN: 1473-0766
Titre abrégé: Gynecol Endocrinol
Pays: England
ID NLM: 8807913
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
5
6
2020
medline:
28
9
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology. To investigate the telomere length in iCPP girls treated with GnRHa. Observational case-control study with 85 girls, including 45 iCPP treated with GnRHa and 40 controls. It was analyzed age, height, weight and body mass index (BMI), insulin, triglycerides, testosterone, insulin resistance by HOMA, and telomere length by real-time PCR. Statistical analyses were determined by Wilcoxon test and Spearman correlation was carried out. Weight, BMI, insulin level and HOMA index were higher in the iCPP than in the control group ( We did not observe any difference in the telomere length in the iCPP and control group. Even though, some characteristics of the disease, such as increased weight and body fat, negatively influence the telomere biology.
Sections du résumé
BACKGROUND
BACKGROUND
Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology.
OBJECTIVE
OBJECTIVE
To investigate the telomere length in iCPP girls treated with GnRHa.
STUDY DESIGN
METHODS
Observational case-control study with 85 girls, including 45 iCPP treated with GnRHa and 40 controls. It was analyzed age, height, weight and body mass index (BMI), insulin, triglycerides, testosterone, insulin resistance by HOMA, and telomere length by real-time PCR. Statistical analyses were determined by Wilcoxon test and Spearman correlation was carried out.
RESULTS
RESULTS
Weight, BMI, insulin level and HOMA index were higher in the iCPP than in the control group (
CONCLUSIONS
CONCLUSIONS
We did not observe any difference in the telomere length in the iCPP and control group. Even though, some characteristics of the disease, such as increased weight and body fat, negatively influence the telomere biology.
Identifiants
pubmed: 32496827
doi: 10.1080/09513590.2020.1770212
doi:
Substances chimiques
Insulin
0
Gonadotropin-Releasing Hormone
33515-09-2
Leuprolide
EFY6W0M8TG
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM