Taste of time: A porous-medium model for human tongue surface with implications for early taste perception.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
02
2020
accepted:
20
04
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Most sensory systems are remarkable in their temporal precision, reflected in such phrases as "a flash of light" or "a twig snap". Yet taste is complicated by the transport processes of stimuli through the papilla matrix to reach taste receptors, processes that are poorly understood. We computationally modeled the surface of the human tongue as a microfiber porous medium and found that time-concentration profiles within the papilla zone rise with significant delay that well match experimental ratings of perceived taste intensity to a range of sweet and salty stimuli for both rapid pulses and longer sip-and-hold exposures. Diffusivity of these taste stimuli, determined mostly by molecular size, correlates greatly with time and slope to reach peak intensity: smaller molecular size may lead to quicker taste perception. Our study demonstrates the novelty of modeling the human tongue as a porous material to drastically simplify computational approaches and that peripheral transport processes may significantly affect the temporal profile of taste perception, at least to sweet and salty compounds.
Identifiants
pubmed: 32497080
doi: 10.1371/journal.pcbi.1007888
pii: PCOMPBIOL-D-20-00270
pmc: PMC7271999
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007888Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC013626
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC017530
Pays : United States
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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