A simple scoring method to predict augmented renal clearance in haematologic malignancies.
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
/ pharmacokinetics
Cohort Studies
Creatinine
/ blood
Critical Illness
Female
Hematologic Neoplasms
/ complications
Humans
Japan
Kidney Function Tests
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Vancomycin
/ pharmacokinetics
augmented renal clearance
haematologic malignancies
risk factors
scoring method
Journal
Journal of clinical pharmacy and therapeutics
ISSN: 1365-2710
Titre abrégé: J Clin Pharm Ther
Pays: England
ID NLM: 8704308
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
14
03
2020
revised:
02
05
2020
accepted:
14
05
2020
pubmed:
5
6
2020
medline:
11
8
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
Augmented renal clearance (ARC; hyperfiltration with over 130 mL/min/1.73 m A single-centre, retrospective, observational cohort study was conducted at the Sendai Medical Center (Sendai, Japan); 133 patients (April 2017-March 2019) and 41 patients (April-November 2019) with haematopoietic tumours who were administered vancomycin were enrolled in the analysis and validation cohorts, respectively. To define ARC, we calculated the vancomycin serum concentration when CL Through multivariate analysis, young age (P < .001), leukaemia (P = .001) and low serum creatinine (P < .001) were identified as risk factors. According to this result, we established the ARC detection method: age ≤ 50 years = 3 points, 50 years < age ≤65 years = 1 point, leukaemia = 2 points, low SCr = 2 points; patients scoring ≥ 5 points represent the ARC high-risk group. Using this scoring system, we could detect ARC with a sensitivity and specificity of 60.0% and 89.7% in the analysis cohort and 90.0% and 90.9% in the validation cohort, respectively. Our scoring method could predict ARC in haematologic malignancies and is useful as a simple screening tool for ARC.
Substances chimiques
Anti-Bacterial Agents
0
Vancomycin
6Q205EH1VU
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Observational Study
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1120-1126Informations de copyright
© 2020 John Wiley & Sons Ltd.
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