N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer's disease.
Abeta
Alzheimer disease
N-terminal truncation
amyloid
antibody
capillary isoelectric focusing immunoassay
Journal
Neuropathology and applied neurobiology
ISSN: 1365-2990
Titre abrégé: Neuropathol Appl Neurobiol
Pays: England
ID NLM: 7609829
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
31
01
2020
accepted:
24
05
2020
pubmed:
5
6
2020
medline:
29
10
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
The deposition of amyloid-β (Aβ) peptides in the form of extracellular plaques in the brain represents one of the classical hallmarks of Alzheimer's disease (AD). In addition to 'full-length' Aβ starting with aspartic acid (Asp-1), considerable amounts of various shorter, N-terminally truncated Aβ peptides have been identified by mass spectrometry in autopsy samples from individuals with AD. Selectivity of several antibodies detecting full-length, total or N-terminally truncated Aβ species has been characterized with capillary isoelectric focusing assays using a set of synthetic Aβ peptides comprising different N-termini. We further assessed the N-terminal heterogeneity of extracellular and vascular Aβ peptide deposits in the human brain by performing immunohistochemical analyses using sporadic AD cases with antibodies targeting different N-terminal residues, including the biosimilar antibodies Bapineuzumab and Crenezumab. While antibodies selectively recognizing Aβ In contrast to other studied Aβ
Identifiants
pubmed: 32497293
doi: 10.1111/nan.12637
pmc: PMC8082844
mid: NIHMS1615734
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antibodies, Monoclonal, Humanized
0
Peptide Fragments
0
bapineuzumab
NC11WKO35D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-685Subventions
Organisme : NIA NIH HHS
ID : RF1 AG059695
Pays : United States
Informations de copyright
© 2020 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.
Références
Chemistry. 2016 Jun 13;22(25):8685-93
pubmed: 27167300
Biochemistry. 1999 Aug 17;38(33):10871-7
pubmed: 10451383
Neuron. 2010 Oct 21;68(2):270-81
pubmed: 20955934
Neurobiol Aging. 2013 Nov;34(11):2564-73
pubmed: 23747045
Neurosci Lett. 2019 May 14;701:125-131
pubmed: 30807796
Neuron. 1995 Feb;14(2):457-66
pubmed: 7857653
Alzheimers Res Ther. 2014 May 26;6(3):28
pubmed: 25031638
Brain Pathol. 2002 Jul;12(3):275-86
pubmed: 12146796
PLoS One. 2016 Mar 16;11(3):e0151615
pubmed: 26982086
Acta Neuropathol. 2019 Feb;137(2):239-257
pubmed: 30426203
Aging Cell. 2016 Apr;15(2):237-44
pubmed: 26751411
EMBO J. 2011 Jun 1;30(11):2255-65
pubmed: 21527912
J Neuroinflammation. 2004 Dec 08;1(1):24
pubmed: 15588287
J Biol Chem. 1995 Oct 13;270(41):23895-8
pubmed: 7592576
Alzheimers Res Ther. 2018 Sep 19;10(1):96
pubmed: 30231896
Alzheimers Res Ther. 2017 Aug 17;9(1):62
pubmed: 28818091
Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12
pubmed: 17245412
Neurology. 2018 May 22;90(21):e1889-e1897
pubmed: 29695589
J Neurosci. 2006 May 17;26(20):5340-6
pubmed: 16707786
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9
pubmed: 3159021
Neuropathol Appl Neurobiol. 2006 Apr;32(2):103-18
pubmed: 16599940
Alzheimers Res Ther. 2016 May 12;8(1):18
pubmed: 27176461
Acta Neuropathol. 2015 Nov;130(5):713-29
pubmed: 26467270
N Engl J Med. 2018 Jan 25;378(4):321-330
pubmed: 29365294
Am J Pathol. 2010 Apr;176(4):1841-54
pubmed: 20228223
Arch Biochem Biophys. 1993 Feb 15;301(1):41-52
pubmed: 8442665
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):208-225
pubmed: 28711595
Acta Neuropathol. 2014;127(6):803-10
pubmed: 24803227
Alzheimers Dement (N Y). 2018 Mar 08;4:150-160
pubmed: 29955659
Acta Neuropathol. 2014;127(6):787-801
pubmed: 24803226
Alzheimers Res Ther. 2012 May 23;4(3):18
pubmed: 22621179
J Clin Invest. 2006 Jan;116(1):193-201
pubmed: 16341263
Alzheimers Res Ther. 2012 Mar 30;4(2):9
pubmed: 22494386
Anal Chem. 2013 Sep 3;85(17):8142-9
pubmed: 23889568
N Engl J Med. 2014 Jan 23;370(4):311-21
pubmed: 24450890
Sci Rep. 2013;3:1302
pubmed: 23416764
Alzheimers Res Ther. 2017 Dec 8;9(1):95
pubmed: 29221491
J Neurosci. 2012 Jul 11;32(28):9677-89
pubmed: 22787053
Acta Neuropathol. 2015 Jan;129(1):1-19
pubmed: 25287911
J Biol Chem. 2014 Nov 14;289(46):32131-32143
pubmed: 25281743
Nat Rev Neurol. 2019 Jul;15(7):365-366
pubmed: 31138932
Acta Neuropathol. 2010 Aug;120(2):185-93
pubmed: 20419305
J Alzheimers Dis. 2015;49(1):101-10
pubmed: 26529393
Science. 2002 Nov 15;298(5597):1379
pubmed: 12434053
Neurology. 1992 Mar;42(3 Pt 1):631-9
pubmed: 1549228
Sci Rep. 2015 Apr 16;5:9649
pubmed: 25880481
Trends Pharmacol Sci. 1991 Oct;12(10):383-8
pubmed: 1763432
Methods Mol Biol. 2018;1779:23-43
pubmed: 29886525
Alzheimers Res Ther. 2017 Oct 4;9(1):80
pubmed: 28978359
Expert Opin Ther Targets. 2019 Dec;23(12):991-1004
pubmed: 31814468
N Engl J Med. 2014 Jan 23;370(4):322-33
pubmed: 24450891
Alzheimers Dement (N Y). 2017 May 10;3(3):339-347
pubmed: 29067341
J Alzheimers Dis. 2018;66(3):1235-1244
pubmed: 30412489
Acta Neuropathol. 2016 Apr;131(4):525-37
pubmed: 26898910
Sci Rep. 2017 Aug 25;7(1):9520
pubmed: 28842697