Microbial Coculture for Flavonoid Synthesis.

Biosynthetic Pathways / genetics Biotechnology / trends Coculture Techniques Flavonoids / biosynthesis Humans Metabolic Engineering Plants / chemistry
flavonoids host selection microbial coculture pathway efficiency population dynamics structural diversity

Journal

Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903

Informations de publication

Date de publication:
07 2020
Historique:
received: 20 11 2019
revised: 29 01 2020
accepted: 29 01 2020
entrez: 5 6 2020
pubmed: 5 6 2020
medline: 16 7 2021
Statut: ppublish

Résumé

Flavonoids are plant-derived natural products with human health-promoting benefits. The modularity and complexity of the flavonoid biosynthetic pathway allow us to leverage the metabolic characteristics of distinct microbial hosts and install structural functionalities beyond what monocultures can achieve. We discuss the promising future of applying microbial cocultures to improve the cost-efficiency and diversity of flavonoid biosynthesis.

Identifiants

DOI: 10.1016/j.tibtech.2020.01.008 PMID: 32497514
pubmed: 32497514
pii: S0167-7799(20)30024-X
doi: 10.1016/j.tibtech.2020.01.008
pii:
doi:

Substances chimiques

Flavonoids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

686-688

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Peng Xu (P)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, MD 21250, USA. Electronic address: pengxu@umbc.edu.

Monireh Marsafari (M)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, MD 21250, USA.

Jian Zha (J)

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China.

Mattheos Koffas (M)

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address: koffam@rpi.edu.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Biotechnologie › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de coculture › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Microbial Coculture for Flavonoid Synthesis.
questionsmedicales.fr › Eucaryotes › Plantes › Microbial Coculture for Flavonoid Synthesis.