Viral depletion of calcitonin receptors in the area postrema: A proof-of-concept study.

Animals Area Postrema / metabolism Islet Amyloid Polypeptide Mice Proto-Oncogene Proteins c-fos / metabolism Receptors, Calcitonin / genetics Solitary Nucleus / metabolism

Journal

Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 31 12 2019
revised: 06 05 2020
accepted: 27 05 2020
pubmed: 5 6 2020
medline: 22 6 2021
entrez: 5 6 2020
Statut: ppublish

Résumé

The area postrema (AP), located in the caudal hindbrain, is one of the primary binding sites for the endocrine satiation hormone amylin. Amylin is co-secreted with insulin from pancreatic ß-cells and binds to heterodimeric receptors that consist of a calcitonin core receptor (CTR) paired with receptor-activity modifying protein (RAMP) 1 or 3. In this study, we aim to validate a CTR-floxed (CTR

Identifiants

DOI: 10.1016/j.physbeh.2020.112992 PMID: 32497530
pubmed: 32497530
pii: S0031-9384(20)30306-1
doi: 10.1016/j.physbeh.2020.112992
pii:
doi:

Substances chimiques

Islet Amyloid Polypeptide 0
Proto-Oncogene Proteins c-fos 0
Receptors, Calcitonin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112992

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Bernd Coester (B)

Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich (UZH), 8057 Zurich, Switzerland. Electronic address: bernd.coester@uzh.ch.

Christelle Le Foll (CL)

Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich (UZH), 8057 Zurich, Switzerland.

Thomas A Lutz (TA)

Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich (UZH), 8057 Zurich, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Organes circumventriculaires › Area postrema › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Protéines amyloïdogènes › Polypeptide amyloïde des ilots › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines proto-oncogènes c-fos › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteurs à la calcitonine › Viral depletion of calcitonin receptors in the...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Myélencéphale › Moelle allongée › Noyau du tractus solitaire › Viral depletion of calcitonin receptors in the...