Effects of high fructose corn syrup on ethanol self-administration in rats.
ethanol
high fructose corn syrup
operant intraoral self-administration
reinstatement
resumption
taste reactivity
Journal
Alcohol (Fayetteville, N.Y.)
ISSN: 1873-6823
Titre abrégé: Alcohol
Pays: United States
ID NLM: 8502311
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
06
01
2020
revised:
22
04
2020
accepted:
20
05
2020
pubmed:
5
6
2020
medline:
15
9
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
The addition of sweeteners to alcoholic beverages is thought to facilitate heavy alcohol consumption, and this may be of particular concern when the additive is high fructose corn syrup (HFCS). Four experiments in male Sprague-Dawley rats were performed to investigate whether the addition of 25% HFCS to ethanol (5%, 10%, and 20% v/v ethanol) would alter its intraoral operant self-administration, palatability, and sensitivity to food deprivation stress. As anticipated, HFCS drastically increased ethanol intake, and this effect appeared driven by its caloric value. Importantly, HFCS increased the persistence of operant responding following extinction in animals trained to self-administer the combination, and the addition of HFCS to ethanol changed subsequent responses to ethanol, including increased palatability and intake. These results in rats suggest that the addition of HFCS to the list of ingredients in sweetened alcoholic beverages could play a significant role in the harmful consumption of ethanol-containing beverages.
Identifiants
pubmed: 32497557
pii: S0741-8329(20)30228-7
doi: 10.1016/j.alcohol.2020.05.003
pii:
doi:
Substances chimiques
High Fructose Corn Syrup
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-88Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.