Divergent Impact of Breast Cancer Laterality on Clinicopathological, Angiogenic, and Hemostatic Profiles: A Potential Role of Tumor Localization in Future Outcomes.
angiogenesis
breast cancer laterality
hemostasis
metastasis
molecular determinants of breast cancer
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
02 Jun 2020
02 Jun 2020
Historique:
received:
25
04
2020
revised:
25
05
2020
accepted:
27
05
2020
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
6
6
2020
Statut:
epublish
Résumé
To date, lateral differences of invasive breast cancer (IBrC) with respect to the angiogenic and hemostatic profiles were never studied. Here, we aimed to determine the relationship of tumor laterality with various clinical and pathological parameters including angiogenic and hemostatic profiles. A total of 92 women that were initially non-metastatic and treated by surgery were included in this single-center prospective study. Patients were grouped according to tumor localization. A four-year follow-up was accomplished in all patients with a 15.22% recurrence rate. An immunoassay of selected angiogenic and hemostatic parameters, as well as immunohistochemistry of estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2), and Ki67, was comparatively performed in groups with right- and left-sided IBrC. The same analysis was carried out in a subgroup of patients with luminal A molecular subtype of cancer. Patients with right-sided tumors free of nodal involvement had a significantly longer overall survival compared to their left-sided counterparts (
Identifiants
pubmed: 32498398
pii: jcm9061708
doi: 10.3390/jcm9061708
pmc: PMC7356400
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Oncol Lett. 2010 Mar;1(2):253-259
pubmed: 22966290
Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):329-34
pubmed: 25304793
Mol Vis. 2016 Jul 25;22:886-97
pubmed: 27499609
Breast Cancer Res. 2006;8(2):R14
pubmed: 16563179
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):656-65
pubmed: 20159360
Breast Cancer Res. 2013;15(4):207
pubmed: 23905544
Radiology. 2011 Dec;261(3):744-51
pubmed: 21878616
Cancer Biol Ther. 2015;16(2):253-60
pubmed: 25587663
Cancer Res. 2008 Jan 15;68(2):521-9
pubmed: 18199548
Prostate Cancer Prostatic Dis. 2012 Jun;15(2):157-64
pubmed: 22183775
Ther Adv Med Oncol. 2018 Jul 13;10:1758835918778297
pubmed: 30023006
Lymphology. 2008 Jun;41(2):75-9
pubmed: 18720914
World J Clin Oncol. 2011 Jun 10;2(6):272-80
pubmed: 21773077
J Egypt Natl Canc Inst. 2004 Mar;16(1):50-6
pubmed: 15716998
BMC Cancer. 2013 Mar 15;13:118
pubmed: 23497249
Cancer Causes Control. 2006 Jun;17(5):655-62
pubmed: 16633912
Clin Chem. 2016 Apr;62(4):563-70
pubmed: 26896447
J Clin Med. 2019 Nov 15;8(11):
pubmed: 31731627
Angiogenesis. 2017 Feb;20(1):85-96
pubmed: 27807692
Cancer Res. 2015 Aug 1;75(15):2969-74
pubmed: 26180080
J Cell Mol Med. 2010 Mar;14(3):528-52
pubmed: 19840194
Cancer Manag Res. 2014 Apr 16;6:191-203
pubmed: 24790468
Biosci Rep. 2018 Mar 29;38(2):
pubmed: 29475895
Anticancer Res. 2014 Mar;34(3):1153-61
pubmed: 24596353
Magn Reson Imaging. 2013 May;31(4):538-44
pubmed: 23219249
Curr Med Chem. 2011;18(36):5519-27
pubmed: 22172062
J Egypt Natl Canc Inst. 2013 Dec;25(4):199-207
pubmed: 24207092
Ann Oncol. 2009 Oct;20(10):1639-46
pubmed: 19549711
Gene Expr Patterns. 2004 Nov;5(1):3-9
pubmed: 15533812
PLoS One. 2014 Apr 16;9(4):e94815
pubmed: 24740002
Breast Cancer Res. 2015 Mar 26;17:44
pubmed: 25882602
Asian Pac J Cancer Prev. 2013;14(1):43-5
pubmed: 23534768