TOCOSH FLOUR (
Solanum tuberosum L.
fermented foods
oral toxicity
tocosh
traditional medicine
Journal
Foods (Basel, Switzerland)
ISSN: 2304-8158
Titre abrégé: Foods
Pays: Switzerland
ID NLM: 101670569
Informations de publication
Date de publication:
02 Jun 2020
02 Jun 2020
Historique:
received:
20
04
2020
revised:
28
05
2020
accepted:
29
05
2020
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
6
6
2020
Statut:
epublish
Résumé
Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD
Identifiants
pubmed: 32498434
pii: foods9060719
doi: 10.3390/foods9060719
pmc: PMC7353511
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
PLoS One. 2017 Mar 3;12(3):e0173039
pubmed: 28257509
Food Chem Toxicol. 2009 Jun;47(6):1099-108
pubmed: 19217925
J Agric Food Chem. 2006 Nov 15;54(23):8655-81
pubmed: 17090106
Food Res Int. 2018 Jul;109:168-174
pubmed: 29803439
Drug Discov Today. 2002 Jun 1;7(11):S83-8
pubmed: 12047885
Dis Mon. 2009 Jun;55(6):391-402
pubmed: 19446683
Foods. 2020 Apr 02;9(4):
pubmed: 32252270
Reprod Toxicol. 2018 Jan;75:96-109
pubmed: 29247839
Chem Res Toxicol. 1996 Mar;9(2):426-33
pubmed: 8839045
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
Foods. 2019 May 10;8(5):
pubmed: 31083345
J Nutr Sci Vitaminol (Tokyo). 2006 Dec;52(6):445-50
pubmed: 17330508
Food Chem Toxicol. 1995 Mar;33(3):191-4
pubmed: 7896228
Anim Reprod Sci. 2005 Feb;85(3-4):243-50
pubmed: 15581508
J Pathol. 2017 Jan;241(1):36-44
pubmed: 27757953
Fundam Appl Toxicol. 1996 Oct;33(2):272-81
pubmed: 8921346
Food Chem. 2013 Nov 15;141(2):669-74
pubmed: 23790833
Food Cosmet Toxicol. 1972 Jun;10(3):395-8
pubmed: 5045682
J Ethnobiol Ethnomed. 2011 Dec 06;7:40
pubmed: 22146009
Genes Nutr. 2019 Apr 2;14:9
pubmed: 30984301
J Contemp Dent Pract. 2019 Oct 1;20(10):1206-1211
pubmed: 31883258
J Am Coll Nutr. 2006 Apr;25(2):155-63
pubmed: 16582033
J Chromatogr A. 2004 Oct 29;1054(1-2):143-55
pubmed: 15553139
J Reprod Fertil. 1976 Jan;46(1):257-9
pubmed: 1271347
World J Gastroenterol. 2010 Nov 14;16(42):5286-96
pubmed: 21072891
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9999-E10008
pubmed: 29087343