The NAIP/NLRC4 inflammasome in infection and pathology.

CARD Signaling Adaptor Proteins / metabolism Calcium-Binding Proteins Flagellin / metabolism Humans Immunity, Innate Inflammasomes / metabolism Neuronal Apoptosis-Inhibitory Protein / metabolism
Caspase Inflammasome NAIP NLRC4 bacterial infection

Journal

Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128

Informations de publication

Date de publication:
12 2020
Historique:
received: 26 02 2020
accepted: 30 04 2020
pubmed: 6 6 2020
medline: 25 9 2021
entrez: 6 6 2020
Statut: ppublish

Résumé

In this review we give an overview of the NAIP/NLRC4 activation mechanism as well as the described roles of this inflammasome, with a focus on in vivo infection and pathology. After ligand recognition by NAIP sensor proteins the NAIP/NLRC4 inflammasome forms through oligomerization with the NLRC4 adaptor to activate Caspase-1. The activating ligands are intracellular bacterial flagellin or type-3 secretion system components, delivered by pathogens. In vivo experiments indicate a role in macrophages during lung, spleen and liver infection and systemic sepsis like conditions, as well as in intestinal epithelial cells. Upon NAIP/NLRC4 activation in the intestine, epithelial cell extrusion is triggered in addition to the canonical inflammasome outcomes of cytokine cleavage and pyroptosis. Human patients with auto-activating mutations in NLRC4 present with an autoinflammatory syndrome including enterocolitis. Although one of the better understood inflammasomes in terms of mechanism, tissue specific functions of NAIP/NLRC4 are only beginning to be understood.

Identifiants

DOI: 10.1016/j.mam.2020.100863 PMID: 32499055
pubmed: 32499055
pii: S0098-2997(20)30024-8
doi: 10.1016/j.mam.2020.100863
pii:
doi:

Substances chimiques

CARD Signaling Adaptor Proteins 0
Calcium-Binding Proteins 0
Inflammasomes 0
NAIP protein, human 0
NLRC4 protein, human 0
Neuronal Apoptosis-Inhibitory Protein 0
Flagellin 12777-81-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100863

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Renate Bauer (R)

Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA; Department of Biosciences, University of Salzburg, A-5020, Salzburg, Austria.

Isabella Rauch (I)

Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA. Electronic address: rauchi@ohsu.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Flagelline › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › The NAIP/NLRC4 inflammasome in infection and pathology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéine inhibitrice de l'apoptose neuronale › The NAIP/NLRC4 inflammasome in infection and pathology.