A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function.

Animals Drosophila / metabolism Endocytosis Endosomes / metabolism Protein Transport Vesicular Transport Proteins / genetics rab GTP-Binding Proteins / genetics rab5 GTP-Binding Proteins / genetics
Drosophila Endosome GEF Lysosome Mon1–Ccz1 complex Nephrocytes Pericardial cells

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
09 07 2020
Historique:
received: 01 04 2020
accepted: 20 05 2020
pubmed: 6 6 2020
medline: 22 6 2021
entrez: 6 6 2020
Statut: epublish

Résumé

Endosome biogenesis in eukaryotic cells is critical for nutrient uptake and plasma membrane integrity. Early endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment of Rab7 to endosomes requires the Mon1-Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the

Identifiants

DOI: 10.1242/jcs.247080 PMID: 32499409
pubmed: 32499409
pii: jcs.247080
doi: 10.1242/jcs.247080
pii:
doi:

Substances chimiques

Vesicular Transport Proteins 0
rab GTP-Binding Proteins EC 3.6.5.2
rab5 GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Lena Dehnen (L)

Department of Biology and Chemistry, Zoology and Developmental Biology, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.

Maren Janz (M)

Department of Biology and Chemistry, Zoology and Developmental Biology, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.

Jitender Kumar Verma (JK)

Department of Biology and Chemistry, Biochemistry, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.

Olympia Ekaterini Psathaki (OE)

Center of Cellular Nanoanalytics, Integrated Bioimaging Facility Osnabrück (iBiOs), University of Osnabrück, 49076 Osnabrück, Germany.

Lars Langemeyer (L)

Department of Biology and Chemistry, Biochemistry, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0002-4309-0910

Florian Fröhlich (F)

Department of Biology and Chemistry, Molecular Membrane Biology, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0001-8307-2189

Jürgen J Heinisch (JJ)

Department of Biology and Chemistry, Genetics, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
Center of Cellular Nanoanalytics, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0003-4197-4285

Heiko Meyer (H)

Department of Biology and Chemistry, Zoology and Developmental Biology, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
Center of Cellular Nanoanalytics, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0002-2631-1910

Christian Ungermann (C)

Department of Biology and Chemistry, Biochemistry, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany paululat@uni-osnabrueck.de cu@uos.de.
Center of Cellular Nanoanalytics, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0003-4331-8695

Achim Paululat (A)

Department of Biology and Chemistry, Zoology and Developmental Biology, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany paululat@uni-osnabrueck.de cu@uos.de.
Center of Cellular Nanoanalytics, University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
ORCID: 0000-0002-8845-6859

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › A trimeric metazoan Rab7 GEF complex is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › Protéines G rab5 › A trimeric metazoan Rab7 GEF complex is...