TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.
innate fear
mouse behavior
neural circuits
optogenetics
viral tracing
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
02
2020
accepted:
08
04
2020
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
6
6
2020
Statut:
epublish
Résumé
A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.
Identifiants
pubmed: 32499680
doi: 10.3389/fncel.2020.00114
pmc: PMC7243865
doi:
Types de publication
Journal Article
Langues
eng
Pagination
114Informations de copyright
Copyright © 2020 Krauth, Khalil, Jariwala, Mermet-Joret, Vestergaard, Capogna and Nabavi.
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