Prospective study of pregnancy outcome between perceived stress and stress-related hormones.
in vitro fertilization-embryo transfer
anxiety
depression
pregnancy outcome
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
20
10
2019
revised:
06
03
2020
accepted:
05
04
2020
pubmed:
6
6
2020
medline:
22
6
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
To evaluate the relationship between physiological and psychological stress on pregnancy outcome in women undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment. Women undergoing the first IVF cycle were enrolled to complete the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). Their blood samples were collected on the 3rd day of the menstrual cycle to measure 5-hydroxytryptamine, renin, norepinephrine, angiotensin II and cortisol. Salivary amylase was obtained on the embryo transfer day. Compared with normal women who came to the hospital for regular physical examination, the incidence of anxiety and depression was higher in women seeking for IVF treatment. After psychological intervention, the condition got improved and the incidence of anxiety and depression was 6.25% and 7.81% separately in these women. There were no significant differences between the anxiety scores in women with and without pregnancy. The depression scores did show some statistically differences, with higher scores in the nonpregnancy group. The level of 5-hydroxytryptamine, renin, norepinephrine and cortisol were not significantly different between the two groups, while angiotensin II and salivary amylase seemed to be negatively correlated with pregnancy outcome. Simultaneously, a positive correlation was found between angiotensin II and anxiety and depression scores. Depression during IVF has a negative impact on pregnancy outcome. The measurement of angiotensin II and salivary amylase might be reference index for the psychological status of patients during IVF-ET.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1355-1363Subventions
Organisme : Science and Technology Project of Jinan
ID : 201602298
Organisme : China Postdoctoral Science Foundation
ID : 2018T110694
Organisme : China Postdoctoral Science Foundation
ID : 2017M610429
Organisme : National Natural Science Foundation of China
ID : 81300459
Informations de copyright
© 2020 Japan Society of Obstetrics and Gynecology.
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