Liquid biopsy markers for stroke diagnosis.
Activated leukocytes
acute ischemic stroke
computed tomography
extracellular vesicles
hemorrhagic stroke
liquid biopsy biomarkers
magnetic resonance imaging
recombinant tissue plasminogen activator
Journal
Expert review of molecular diagnostics
ISSN: 1744-8352
Titre abrégé: Expert Rev Mol Diagn
Pays: England
ID NLM: 101120777
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
6
6
2020
medline:
28
9
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
There is a short time window (4.5 h) for the effective treatment of acute ischemic stroke (AIS), which uses recombinant tissue plasminogen activator (rt-PA). Unfortunately, this short therapeutic timeframe is a contributing factor to the relatively small number of patients (~7%) that receive rt-PA. While neuroimaging is the major diagnostic for AIS, more timely decisions could be made using a molecular diagnostic. In this review, we survey neuroimaging techniques used to diagnose stroke and their limitations. We also highlight the potential of various molecular/cellular biomarkers, especially peripheral blood-based ( While there are a plethora of molecular markers for stroke diagnosis that have been reported, they have yet to be FDA-cleared. Possible reasons include the inability for these markers to appear in sufficient quantities for highly sensitive clinical decisions within the rt-PA therapeutic time.
Identifiants
pubmed: 32500751
doi: 10.1080/14737159.2020.1777859
pmc: PMC8157911
mid: NIHMS1603204
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
771-788Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130423
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB020594
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB010087
Pays : United States
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