Assessing the effectiveness of actionable nutrigenomics and lifestyle genomics interventions for weight management in clinical practice: A critical, scoping review with directions for future research.

Body Mass Index Body Weight Genomics / trends Humans Life Style Nutrigenomics / trends
Nutrigenomics lifestyle genomics nutrigenetics nutrition obesity overweight physical activity

Journal

Nutrition and health
ISSN: 0260-1060
Titre abrégé: Nutr Health
Pays: England
ID NLM: 8306569

Informations de publication

Date de publication:
Sep 2020
Historique:
pubmed: 6 6 2020
medline: 6 5 2021
entrez: 6 6 2020
Statut: ppublish

Résumé

The use of nutrigenomics and lifestyle genomics in clinical practice has the potential to optimize weight-related outcomes for patients. A scoping review was conducted to summarize and evaluate the current body of knowledge related to the effectiveness of providing DNA-based lifestyle advice on weight-related outcomes, with the aim of providing direction for future research. Primary studies were included if they were written in English, evaluated weight-related and/or body mass index and/or body composition outcomes, and provided participants with an actionable genetic-based lifestyle intervention; interventions that only provided information on genetic risk for diseases/conditions were excluded. Data was extracted from each article meeting inclusion criteria ( Research in this area is promising, but limited. Specific limitations relate to study designs, the nature of the recommendations provided to participants, small (underpowered) sample sizes, the use of self-reported weight/BMI data and lack of consideration of important confounding factors. Therefore, the effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined. Recommendations for future research are detailed in the present manuscript.

Sections du résumé

BACKGROUND BACKGROUND
The use of nutrigenomics and lifestyle genomics in clinical practice has the potential to optimize weight-related outcomes for patients.
AIM OBJECTIVE
A scoping review was conducted to summarize and evaluate the current body of knowledge related to the effectiveness of providing DNA-based lifestyle advice on weight-related outcomes, with the aim of providing direction for future research.
METHOD METHODS
Primary studies were included if they were written in English, evaluated weight-related and/or body mass index and/or body composition outcomes, and provided participants with an actionable genetic-based lifestyle intervention; interventions that only provided information on genetic risk for diseases/conditions were excluded. Data was extracted from each article meeting inclusion criteria (
RESULTS RESULTS
Research in this area is promising, but limited. Specific limitations relate to study designs, the nature of the recommendations provided to participants, small (underpowered) sample sizes, the use of self-reported weight/BMI data and lack of consideration of important confounding factors.
CONCLUSIONS CONCLUSIONS
Therefore, the effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined. Recommendations for future research are detailed in the present manuscript.

Identifiants

DOI: 10.1177/0260106020928667 PMID: 32500817
pubmed: 32500817
doi: 10.1177/0260106020928667
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

167-173

Auteurs

Justine Horne (J)

Health and Rehabilitation Sciences, The University of Western Ontario, London,.ON, Canada.
The East Elgin Family Health Team, Aylmer, ON, Canada.
Human Environments Analysis Laboratory, The University of Western Ontario, London, ON, Canada.
ORCID: 0000-0002-9176-9645

Jason Gilliland (J)

Human Environments Analysis Laboratory, The University of Western Ontario, London, ON, Canada.
Department of Geography, Western University, London, ON, Canada.
Human Environments Analysis Laboratory, Western University, London, ON, Canada.
School of Health Studies, Western University, London, ON, Canada.
Department of Paediatrics, Western University, London, ON, Canada.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Children's Health Research Institute, London, ON, Canada.
Lawson Health Research Institute, London, ON, Canada.

Janet Madill (J)

Human Environments Analysis Laboratory, Western University, London, ON, Canada.
School of Food and Nutritional Sciences, Brescia University College at Western University, London, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Assessing the effectiveness of actionable...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Assessing the effectiveness of actionable...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Assessing the effectiveness of actionable...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Assessing the effectiveness of actionable...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Assessing the effectiveness of actionable...
questionsmedicales.fr › Professions de santé › Sciences de la nutrition › Nutrigénomique › Assessing the effectiveness of actionable...