Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes.
7-GS-DHP
DHP
Pyrrolizidine alkaloid
cysteine
glutathione
Journal
Journal of environmental science and health. Part C, Toxicology and carcinogenesis
ISSN: 2689-6591
Titre abrégé: J Environ Sci Health C Toxicol Carcinog
Pays: United States
ID NLM: 101766761
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
22
9
2021
Statut:
ppublish
Résumé
Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic phytochemicals. Upon metabolic activation, PAs produce dehydropyrrolizidine alkaloids (dehydro-PAs) as reactive primary pyrrolic metabolites. Dehydro-PAs are unstable, facilely hydrolyzed to (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5
Identifiants
pubmed: 32500832
doi: 10.1080/26896583.2020.1738161
doi:
Substances chimiques
7-cysteine-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine
0
7-glutathione-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine
0
Carcinogens
0
Pyrrolizidine Alkaloids
0
riddelliine
23246-96-0
Monocrotaline
73077K8HYV
Glutathione
GAN16C9B8O
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM