A study on the correlation between remnant cholesterol and urinary albumin to creatinine ratio in Chinese community adults: A report from the REACTION study.
atherosclerosis
remnant cholesterol
urinary albumin to creatinine ratio
动脉粥样硬化
尿白蛋白肌酐比值
残余胆固醇
Journal
Journal of diabetes
ISSN: 1753-0407
Titre abrégé: J Diabetes
Pays: Australia
ID NLM: 101504326
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
03
2020
revised:
21
05
2020
accepted:
29
05
2020
pubmed:
6
6
2020
medline:
3
11
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
The correlation between remnant cholesterol (RC) and urinary albumin to creatinine ratio (UACR) has not been illustrated. The present study aims to explore the correlation between RC levels and UACR in Chinese community adults. This study included 35 848 participants from a cohort study (REACTION). The UACR data were divided into three groups: UACR <10 mg/g, 10 ≤UACR<30 mg/g, and UACR ≥30 mg/g groups. RC was divided into two groups, according to the 75th percentile: <75% group and ≥75% group. Multiple logistic regression analysis was used to evaluate the correlation between RC and UACR. The RC exhibited an adjusted odds ratio that was significant in models 1-5. Although all confounders were corrected in model 5, RC and UACR were still significantly correlated， and the correlation was more significant in females，when compared to males (odds ratio [OR]: 1.117, 95% CI: 1.063-1.176, P < 0.001 for all subjects; OR: 1.092, 95% CI: 1.128-1.161, P = 0.004 for females; and OR: 1.085, 95% CI: 0.998-1.194, P = 0.088 for males). The RC was significantly correlated with UACR for subjects with 5.6 ≤ fasting blood glucose < 7.0 or 7.8 ≤ post-load blood glucose < 11.1 mmol/L, 24 ≤ body mass index (BMI) < 28 kg/m In the Chinese community, RC is highly correlated with UACR, and the correlation is more significant in females compared with males. At higher RC levels, patients with critical values of blood pressure, BMI and blood glucose have a more significant correlation between RC and UACR. 背景: 残余胆固醇(RC)和尿白蛋白肌酐比值(UACR)之间的相关性尚未被阐明。本研究旨在探讨中国社区成年人群中RC水平与UACR的相关性。 方法: 本研究纳入来自一个队列研究(REACTION研究)的35848名参与者。UACR分为三组: UACR< 10 mg/g、 10≤UACR<30 mg/g和UACR≥30 mg/g组。根据第75百分位，RC被分为两组: <75%组和≥75%组。采用多元逻辑回归分析评估RC与UACR的相关性。 结果: 在模型1-5中，RC显示出显著的校正后优势比(OR)。尽管模型5中校正了所有混杂因素，RC和UACR仍然显著相关，并且与男性相比，这种相关性在女性中更为显著(对于所有受试者:OR: 1.117, 95% CI: 1.063-1.176, P < 0.001；对于女性受试者:OR: 1.092, 95% CI: 1.128-1.161, P = 0.004；对于男性受试者:OR: 1.085, 95% CI: 0.998-1.194, P = 0.088)。对于5.6≤空腹血糖< 7.0 mmol/L或7.8≤餐后血糖< 11.1 mmol/L，24≤体重指数(BMI)< 28 kg/m
Sections du résumé
BACKGROUND
BACKGROUND
The correlation between remnant cholesterol (RC) and urinary albumin to creatinine ratio (UACR) has not been illustrated. The present study aims to explore the correlation between RC levels and UACR in Chinese community adults.
METHODS
METHODS
This study included 35 848 participants from a cohort study (REACTION). The UACR data were divided into three groups: UACR <10 mg/g, 10 ≤UACR<30 mg/g, and UACR ≥30 mg/g groups. RC was divided into two groups, according to the 75th percentile: <75% group and ≥75% group. Multiple logistic regression analysis was used to evaluate the correlation between RC and UACR.
RESULTS
RESULTS
The RC exhibited an adjusted odds ratio that was significant in models 1-5. Although all confounders were corrected in model 5, RC and UACR were still significantly correlated， and the correlation was more significant in females，when compared to males (odds ratio [OR]: 1.117, 95% CI: 1.063-1.176, P < 0.001 for all subjects; OR: 1.092, 95% CI: 1.128-1.161, P = 0.004 for females; and OR: 1.085, 95% CI: 0.998-1.194, P = 0.088 for males). The RC was significantly correlated with UACR for subjects with 5.6 ≤ fasting blood glucose < 7.0 or 7.8 ≤ post-load blood glucose < 11.1 mmol/L, 24 ≤ body mass index (BMI) < 28 kg/m
CONCLUSIONS
CONCLUSIONS
In the Chinese community, RC is highly correlated with UACR, and the correlation is more significant in females compared with males. At higher RC levels, patients with critical values of blood pressure, BMI and blood glucose have a more significant correlation between RC and UACR.
背景: 残余胆固醇(RC)和尿白蛋白肌酐比值(UACR)之间的相关性尚未被阐明。本研究旨在探讨中国社区成年人群中RC水平与UACR的相关性。 方法: 本研究纳入来自一个队列研究(REACTION研究)的35848名参与者。UACR分为三组: UACR< 10 mg/g、 10≤UACR<30 mg/g和UACR≥30 mg/g组。根据第75百分位，RC被分为两组: <75%组和≥75%组。采用多元逻辑回归分析评估RC与UACR的相关性。 结果: 在模型1-5中，RC显示出显著的校正后优势比(OR)。尽管模型5中校正了所有混杂因素，RC和UACR仍然显著相关，并且与男性相比，这种相关性在女性中更为显著(对于所有受试者:OR: 1.117, 95% CI: 1.063-1.176, P < 0.001；对于女性受试者:OR: 1.092, 95% CI: 1.128-1.161, P = 0.004；对于男性受试者:OR: 1.085, 95% CI: 0.998-1.194, P = 0.088)。对于5.6≤空腹血糖< 7.0 mmol/L或7.8≤餐后血糖< 11.1 mmol/L，24≤体重指数(BMI)< 28 kg/m
Autres résumés
Type: Publisher
(chi)
背景: 残余胆固醇(RC)和尿白蛋白肌酐比值(UACR)之间的相关性尚未被阐明。本研究旨在探讨中国社区成年人群中RC水平与UACR的相关性。 方法: 本研究纳入来自一个队列研究(REACTION研究)的35848名参与者。UACR分为三组: UACR< 10 mg/g、 10≤UACR<30 mg/g和UACR≥30 mg/g组。根据第75百分位，RC被分为两组: <75%组和≥75%组。采用多元逻辑回归分析评估RC与UACR的相关性。 结果: 在模型1-5中，RC显示出显著的校正后优势比(OR)。尽管模型5中校正了所有混杂因素，RC和UACR仍然显著相关，并且与男性相比，这种相关性在女性中更为显著(对于所有受试者:OR: 1.117, 95% CI: 1.063-1.176, P < 0.001；对于女性受试者:OR: 1.092, 95% CI: 1.128-1.161, P = 0.004；对于男性受试者:OR: 1.085, 95% CI: 0.998-1.194, P = 0.088)。对于5.6≤空腹血糖< 7.0 mmol/L或7.8≤餐后血糖< 11.1 mmol/L，24≤体重指数(BMI)< 28 kg/m
Identifiants
pubmed: 32500969
doi: 10.1111/1753-0407.13076
doi:
Substances chimiques
Blood Glucose
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
870-880Subventions
Organisme : Chinese Society of Endocrinology
Organisme : National Science and Technology Major Project
Organisme : the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health
Organisme : the National High Technology Research and Development Program of China
Organisme : the National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology
Organisme : National Science and Technology Major Project 288
ID : 2011ZX09307-001-08
Organisme : National High Technology Research and Development Program of China
ID : 2011AA020107
Organisme : National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology
ID : 2012ZX09303006-001
Organisme : Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health
ID : 1994DP131044
Informations de copyright
© 2020 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
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