T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice.

Adenosine / administration & dosage Aging / drug effects Animals Cellular Senescence / drug effects Cognitive Dysfunction / immunology Disease Models, Animal Galactose / administration & dosage Gastrodia / chemistry Hippocampus / cytology Humans Male Mice Neurogenesis / drug effects Neurons / drug effects Oxidative Stress / drug effects Reactive Oxygen Species / metabolism
T1-11 adenosine analog anti-neuroinflammation neurogenesis senescence

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
05 06 2020
Historique:
received: 27 05 2019
accepted: 20 04 2020
pubmed: 6 6 2020
medline: 9 3 2021
entrez: 6 6 2020
Statut: ppublish

Résumé

Aging is a natural human process. It is uniquely individual, taking into account experiences, lifestyle habits and environmental factors. However, many disorders and syndromes, such as osteoporosis, neurodegenerative disorders, cognitive decline etc., often come with aging. The present study was designed to investigate the possible anti-aging effect of

Identifiants

DOI: 10.18632/aging.103279 PMID: 32501291 PMC: PMC7346012
pubmed: 32501291
doi: 10.18632/aging.103279
pii: 103279
pmc: PMC7346012
doi:

Substances chimiques

N6-(4-hydroxybenzyl)adenosine 0
Reactive Oxygen Species 0
Adenosine K72T3FS567
Galactose X2RN3Q8DNE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10556-10577

Références

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Auteurs

Wei-Hsiang Hsu (WH)

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.

Young-Ji Shiao (YJ)

National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan.
Institute of Biopharmaceutical Science, National Yang-Ming University, Taipei 112, Taiwan.

Yen-Ming Chao (YM)

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.

Yi-Jeng Huang (YJ)

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.

Yun-Lian Lin (YL)

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.
Department of Pharmacy, National Taiwan University, Taipei 10050, Taiwan.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Galactose › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Gastrodia › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Cellules › Neurones › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › T1-11, an adenosine derivative, ameliorates...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › T1-11, an adenosine derivative, ameliorates...