Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity.
Angiotensin converting enzyme 2
Coronavirus
Cytokines
Obesity
Vitamin D
Journal
Obesity medicine
ISSN: 2451-8476
Titre abrégé: Obes Med
Pays: England
ID NLM: 101690300
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
16
05
2020
revised:
18
05
2020
accepted:
21
05
2020
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
6
6
2020
Statut:
ppublish
Résumé
As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
Identifiants
pubmed: 32501427
doi: 10.1016/j.obmed.2020.100259
pii: S2451-8476(20)30079-8
pii: 100259
pmc: PMC7255205
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100259Informations de copyright
© 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declare no conflict of interest.
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