Associations Between Body Weight, Hippocampal Volume, and Tissue Signal Intensity in 12- to 18-Year-Olds.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
02
10
2019
revised:
14
04
2020
accepted:
15
04
2020
pubmed:
6
6
2020
medline:
7
4
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
The hippocampus is a key structure in feeding behaviors and weight regulation. Obesity may lead to disruptions in hippocampal structure. In animals, obesity-related factors (e.g., high-fat/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, a critical brain development period. This study examined hippocampal volume and tissue signal intensity in adolescents across the weight spectrum. Structural magnetic resonance imaging and anthropomorphic data were available for 102 12- to 18-year-old adolescents (53% female; 15.07 [SD 1.84] years; standardized BMI [BMIz] scores using the Centers for Disease Control and Prevention growth charts: 0.54 [SD 1.17]) from the Pediatric Imaging, Neurocognition, and Genetics database. Linear regression models controlling for age, sex, genetic ancestry, scanner, and household income examined the relationship between BMIz, hippocampal volume, and T2-weighted hippocampal signal intensity. BMIz was negatively associated with T2-weighted hippocampal signal intensity in the left (t = -3.05; P = 0.003; r = -0.21) and right (t = -2.50; P = 0.01; r = -0.36) hippocampi. BMIz was not significantly associated with hippocampal volume. BMIz is associated with hippocampal tissue characteristics during adolescence, which could impact later brain development.
Identifiants
pubmed: 32501641
doi: 10.1002/oby.22841
pmc: PMC7927957
mid: NIHMS1585300
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1325-1331Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK114480
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31DK117556
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23DK114480
Pays : United States
Organisme : NIDA NIH HHS
ID : R01HD061414
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD061414
Pays : United States
Organisme : NIDA NIH HHS
ID : RC2 DA029475
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK117556
Pays : United States
Organisme : NIDA NIH HHS
ID : RC2DA029475
Pays : United States
Informations de copyright
© 2020 The Obesity Society.
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