Serum SYPL1 is a promising diagnostic biomarker for colorectal cancer.
Biomarker
Colorectal cancer
SYPL1
Serum
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
14
02
2020
revised:
14
05
2020
accepted:
28
05
2020
pubmed:
6
6
2020
medline:
26
5
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
At present, the overall sensitivity and specificity of blood biomarkers are insufficient for a diagnosis of colorectal cancer (CRC). We analyzed the serum synaptophysin like 1 (sSYPL1) in controls, adenoma patients, CRC patients, pre- and postoperative CRC patients by ELISA. The upregulation of SYPL1 was confirmed in CRC tissues at both mRNA and protein levels. Consistently, sSYPL1 was significantly higher in CRC patients than in either controls (t = 14.50, P < 0.0001) or adenoma patients (t = 10.56, P < 0.0001) and was associated with lymph node invasion (χ sSYPL1 might be an outstanding marker for CRC diagnosis, especially for patients with low CEA levels.
Sections du résumé
BACKGROUND
BACKGROUND
At present, the overall sensitivity and specificity of blood biomarkers are insufficient for a diagnosis of colorectal cancer (CRC).
METHODS
METHODS
We analyzed the serum synaptophysin like 1 (sSYPL1) in controls, adenoma patients, CRC patients, pre- and postoperative CRC patients by ELISA.
RESULTS
RESULTS
The upregulation of SYPL1 was confirmed in CRC tissues at both mRNA and protein levels. Consistently, sSYPL1 was significantly higher in CRC patients than in either controls (t = 14.50, P < 0.0001) or adenoma patients (t = 10.56, P < 0.0001) and was associated with lymph node invasion (χ
CONCLUSION
CONCLUSIONS
sSYPL1 might be an outstanding marker for CRC diagnosis, especially for patients with low CEA levels.
Identifiants
pubmed: 32502495
pii: S0009-8981(20)30262-X
doi: 10.1016/j.cca.2020.05.048
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
CA-19-9 Antigen
0
Carcinoembryonic Antigen
0
Synaptophysin
0
SYPL1 protein, human
159447-27-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
36-42Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.