Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots.
Bisindole alkaloids
Isatindigosides H–J
Isatis indigotica
Isatisindigoticanines J and K
Nitric oxide production
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
03
05
2020
revised:
30
05
2020
accepted:
31
05
2020
pubmed:
6
6
2020
medline:
23
3
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
Eight bisindole alkaloids including six undescribed ones (1a/1b-5) were isolated from an alcohol extract of the Isatis indigotica roots. Their structures and absolute configurations were supported by extensive spectroscopic data analysis, including 1D, 2D NMR, HRESIMS data, specific rotation data, and comparison of the experimental and calculated ECD data. Compounds 1a and 1b were determined to be a pair of enantiomers with a ratio of approximately 1:1 by chiral-phase chromatography analysis while compound 4 was elucidated as a new type of bisindole alkaloid with the aglycone categorized as bis(indole-1'/3″-yl)methane. All the isolated compounds were tested for their nitric oxide (NO) inhibitory effects and 1-4 and 6 exhibited inhibitory effects with IC
Identifiants
pubmed: 32502502
pii: S0367-326X(20)30236-7
doi: 10.1016/j.fitote.2020.104654
pii:
doi:
Substances chimiques
Alkaloids
0
Phytochemicals
0
Plant Extracts
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104654Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest.