Diagnostic, prognostic, and therapeutic significance of miR-139-5p in cancers.
Cancer
Signaling pathway
miR-139-5p
miRNA
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
20
04
2020
revised:
23
05
2020
accepted:
27
05
2020
pubmed:
6
6
2020
medline:
1
9
2020
entrez:
6
6
2020
Statut:
ppublish
Résumé
miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either promote or suppress tumor development by mediating different signaling pathways. miR-139-5p, located on chromosome 11q13.4, has been examined extensively in cancers. Studies have demonstrated that miR-139-5p might be an attractive cancer biomarker. Herein, we will review how miR-139-5p acts in cancer diagnosis, prognosis, and therapy, as well as elucidating its major target genes and associated signaling pathways.
Identifiants
pubmed: 32502540
pii: S0024-3205(20)30615-9
doi: 10.1016/j.lfs.2020.117865
pii:
doi:
Substances chimiques
MIRN139 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117865Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflict of interest.