Confound modelling in UK Biobank brain imaging.
Big data imaging
Confounds
Data modelling
Epidemiological studies
Image analysis
Machine learning
Multi-modal data integration
Statistica l modelling
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
11
03
2020
revised:
08
05
2020
accepted:
25
05
2020
pubmed:
6
6
2020
medline:
30
3
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
Dealing with confounds is an essential step in large cohort studies to address problems such as unexplained variance and spurious correlations. UK Biobank is a powerful resource for studying associations between imaging and non-imaging measures such as lifestyle factors and health outcomes, in part because of the large subject numbers. However, the resulting high statistical power also raises the sensitivity to confound effects, which therefore have to be carefully considered. In this work we describe a set of possible confounds (including non-linear effects and interactions that researchers may wish to consider for their studies using such data). We include descriptions of how we can estimate the confounds, and study the extent to which each of these confounds affects the data, and the spurious correlations that may arise if they are not controlled. Finally, we discuss several issues that future studies should consider when dealing with confounds.
Identifiants
pubmed: 32502668
pii: S1053-8119(20)30488-2
doi: 10.1016/j.neuroimage.2020.117002
pmc: PMC7610719
mid: EMS123322
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117002Subventions
Organisme : Wellcome Trust
ID : 098369/Z/12/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098369
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Neuroimage. 2017 Feb 1;146:959-970
pubmed: 27746386
J Magn Reson Imaging. 2019 Dec;50(6):1948-1954
pubmed: 31111981
Neuroimage. 2017 Jul 1;154:188-205
pubmed: 27989777
Neuroimage. 2014 Sep;98:405-15
pubmed: 24791746
Neuroimage. 2017 May 15;152:450-466
pubmed: 28284799
Neuroimage. 2019 Jan 1;184:801-812
pubmed: 30267859
Neuroimage. 2018 Apr 1;169:407-418
pubmed: 29278774
Psychometrika. 2013 Jul;78(3):396-416
pubmed: 25106392
Neuroimage. 2017 Apr 15;150:23-49
pubmed: 28143776
Neuroimage. 2013 Jan 1;64:240-56
pubmed: 22926292
Neuroimage. 2019 Oct 15;200:575-589
pubmed: 31108215
PLoS One. 2016 Mar 31;11(3):e0152719
pubmed: 27031707
PLoS One. 2015 Nov 05;10(11):e0142014
pubmed: 26540239
Kidney Int. 2008 Feb;73(3):256-60
pubmed: 17978811
Neuroimage. 2019 Apr 1;189:116-129
pubmed: 30633965
Nat Neurosci. 2016 Nov;19(11):1523-1536
pubmed: 27643430
Hum Brain Mapp. 2006 Oct;27(10):779-88
pubmed: 16456818
Hum Brain Mapp. 2017 Jan;38(1):472-492
pubmed: 27634551
Neuroimage. 2011 Jun 1;56(3):1164-70
pubmed: 21324367
J Neurosci Methods. 2014 Jun 15;230:37-50
pubmed: 24785589
Neuroimage. 2018 Feb 1;166:400-424
pubmed: 29079522
Neuroimage. 2010 Dec;53(4):1244-55
pubmed: 20600995
Neuroimage. 2017 Jul 1;154:169-173
pubmed: 27888059
Neuroimage. 2002 Sep;17(1):479-89
pubmed: 12482100
Neuroimage. 2019 Jan 1;184:741-760
pubmed: 30268846
J Magn Reson Imaging. 2012 Nov;36(5):1234-40
pubmed: 22570196
Neuroimage. 2014 Jan 1;84:320-41
pubmed: 23994314
PLoS One. 2020 Apr 20;15(4):e0231627
pubmed: 32310977
Neuroimage. 2001 Dec;14(6):1370-86
pubmed: 11707093
Nat Genet. 2012 Apr 15;44(5):552-61
pubmed: 22504417
Aging (Albany NY). 2019 Aug 26;11(16):5943-5974
pubmed: 31480020
Neuron. 2018 Jan 17;97(2):263-268
pubmed: 29346749
Neuroimage. 2018 May 15;172:291-312
pubmed: 29307608
PLoS One. 2011;6(7):e22193
pubmed: 21829449
Neuroimage. 2016 Nov 1;141:556-572
pubmed: 27393418
Neuroimage. 2013 Oct 15;80:349-59
pubmed: 23571418
Nature. 2018 Oct;562(7726):210-216
pubmed: 30305740
Neuroimage. 2014 Jul 15;95:232-47
pubmed: 24657355
Bioinformatics. 2003 Jan 22;19(2):185-93
pubmed: 12538238
Neuroimage. 2017 Oct 1;159:57-69
pubmed: 28712995
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946