Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art.
adjuvancy
controlled release
immune activation
injectable parenteral formulations
nanotechnology
solubility enhancement
targeting
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
29
04
2020
accepted:
24
05
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
7
6
2020
Statut:
epublish
Résumé
Within recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production of various injectable parenteral formulations. Indeed, recent decades have witnessed a rapid growth of the marketed and pipeline nanotechnology-based injectable products, which is a testimony to the remarkability of the aforementioned contribution. Adjunct to the ability of nanomaterials to deliver the incorporated payloads to many different targets of interest, nanotechnology has substantially assisted to the development of many further facets of the art. Such contributions include the enhancement of the drug solubility, development of long-acting locally and systemically injectable formulations, tuning the onset of the drug's release through the endowment of sensitivity to various internal or external stimuli, as well as adjuvancy and immune activation, which is a desirable component for injectable vaccines and immunotherapeutic formulations. The current work seeks to provide a comprehensive review of all the abovementioned contributions, along with the most recent advances made within each domain. Furthermore, recent developments within the domains of passive and active targeting will be briefly debated.
Identifiants
pubmed: 32503171
pii: pharmaceutics12060510
doi: 10.3390/pharmaceutics12060510
pmc: PMC7356945
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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