Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain.
PAG
VTA
acupuncture
chronic low back pain
descending pain modulation system
functional connectivity
reward network
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
01
05
2020
revised:
22
05
2020
accepted:
22
05
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
7
6
2020
Statut:
epublish
Résumé
Chronic low back pain (cLBP) is a common disorder with unsatisfactory treatment options. Acupuncture has emerged as a promising method for treating cLBP. However, the mechanism underlying acupuncture remains unclear. In this study, we investigated the modulation effects of acupuncture on resting state functional connectivity (rsFC) of the periaqueductal gray (PAG) and ventral tegmental area (VTA) in patients with cLBP. Seventy-nine cLBP patients were recruited and assigned to four weeks of real or sham acupuncture. Resting state functional magnetic resonance imaging data were collected before the first and after the last treatment. Fifty patients completed the study. We found remission of pain bothersomeness in all treatment groups after four weeks, with greater pain relief after real acupuncture compared to sham acupuncture. We also found that real acupuncture can increase VTA/PAG rsFC with the amygdala, and the increased rsFC was associated with decreased pain bothersomeness scores. Baseline PAG-amygdala rsFC could predict four-week treatment response. Our results suggest that acupuncture may simultaneously modulate the rsFC of key regions in the descending pain modulation (PAG) and reward systems (VTA), and the amygdala may be a key node linking the two systems to produce antinociceptive effects. Our findings highlight the potential of acupuncture for chronic low back pain management.
Identifiants
pubmed: 32503194
pii: jcm9061719
doi: 10.3390/jcm9061719
pmc: PMC7356178
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCCIH NIH HHS
ID : P01 AT006663
Pays : United States
Organisme : NCCIH NIH HHS
ID : R33 AT009341
Pays : United States
Organisme : NIDA NIH HHS
ID : R34 DA046635
Pays : United States
Organisme : NIH HHS
ID : R01 AT008563, R33 AT009310, R33AT009341, R34DA046635, R01AG063975
Pays : United States
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