HMGA Proteins in Hematological Malignancies.
HMGA proteins
hematologic malignancies
molecular markers
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
22
04
2020
revised:
25
05
2020
accepted:
01
06
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
7
6
2020
Statut:
epublish
Résumé
The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as "architectural transcriptional factors". By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulating gene expression by either enhancing or suppressing the binding of the more usual transcriptional activators and repressors, although they do not themselves have any transcriptional activity. Their involvement in both benign and malignant neoplasias is well-known and supported by a large volume of studies. In this review, we focus on the role of the HMGA proteins in hematological malignancies, exploring the mechanisms through which they enhance neoplastic transformation and how this knowledge could be exploited to devise tailored therapeutic strategies.
Identifiants
pubmed: 32503270
pii: cancers12061456
doi: 10.3390/cancers12061456
pmc: PMC7353061
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Cell Stem Cell. 2008 Nov 6;3(5):469-70
pubmed: 18983959
Blood Cancer J. 2014 Jul 11;4:e227
pubmed: 25014774
Cell Stem Cell. 2018 Apr 5;22(4):575-588.e7
pubmed: 29625070
J Immunol. 1995 Nov 1;155(9):4330-8
pubmed: 7594592
Cancer Res. 1999 Oct 1;59(19):4793-7
pubmed: 10519386
Blood. 2011 Jun 2;117(22):5860-9
pubmed: 21460244
J Biol Chem. 1999 Aug 6;274(32):22563-8
pubmed: 10428834
Blood Cancer J. 2018 Jul 19;8(8):68
pubmed: 30061630
Cell Cycle. 2012 Mar 1;11(5):922-33
pubmed: 22333591
Cancer Res. 2005 Nov 1;65(21):10050-8
pubmed: 16267031
Br J Haematol. 2015 Feb;168(3):338-49
pubmed: 25236537
Histol Histopathol. 2012 May;27(5):567-79
pubmed: 22419021
Oncogene. 2002 May 9;21(20):3190-8
pubmed: 12082634
Blood. 2011 Mar 24;117(12):3302-10
pubmed: 21239698
Lancet. 2005 Mar 19-25;365(9464):1054-61
pubmed: 15781101
Blood. 2014 May 1;123(18):2826-37
pubmed: 24668492
Biochem J. 2003 May 15;372(Pt 1):145-50
pubmed: 12573034
Clin Cancer Res. 2011 Apr 15;17(8):2570-80
pubmed: 21252160
Nucleic Acids Res. 1996 Oct 15;24(20):4071-7
pubmed: 8918814
Oncogene. 2002 May 2;21(19):2971-80
pubmed: 12082527
Nature. 2005 Apr 28;434(7037):1144-8
pubmed: 15793561
J Biol Chem. 2001 Mar 23;276(12):9550-7
pubmed: 11124259
Int J Mol Med. 2019 Aug;44(2):427-436
pubmed: 31173171
Cell. 2007 Dec 14;131(6):1109-23
pubmed: 18083101
Mol Cell Biol. 2001 Jan;21(1):224-34
pubmed: 11113197
Science. 2008 Apr 4;320(5872):97-100
pubmed: 18292307
Genes Chromosomes Cancer. 2007 Apr;46(4):336-47
pubmed: 17243163
Science. 2004 Oct 8;306(5694):269-71
pubmed: 15472075
CA Cancer J Clin. 2016 Jul;66(4):271-89
pubmed: 27253694
Int J Oncol. 2008 Feb;32(2):289-305
pubmed: 18202751
Cell Res. 2011 Mar;21(3):518-29
pubmed: 21243013
J Hematol Oncol. 2012 Aug 08;5:48
pubmed: 22873195
Cell. 1987 Dec 24;51(6):975-85
pubmed: 3690667
J Clin Oncol. 2012 Dec 20;30(36):4515-23
pubmed: 22987078
Cancer Res. 2007 Feb 15;67(4):1461-71
pubmed: 17308084
Blood. 1995 Jul 15;86(2):755-60
pubmed: 7606004
N Engl J Med. 2010 Sep 16;363(12):1117-27
pubmed: 20843246
Blood. 2005 Sep 1;106(5):1839-42
pubmed: 15878978
Anticancer Agents Med Chem. 2016;16(1):29-37
pubmed: 26179270
Mol Cancer Ther. 2006 Feb;5(2):279-86
pubmed: 16505101
J Natl Compr Canc Netw. 2012 Aug;10(8):984-1021
pubmed: 22878824
Eur J Pharmacol. 2018 Nov 5;838:32-40
pubmed: 30194939
Nature. 2000 Feb 24;403(6772):901-6
pubmed: 10706289
Science. 2007 Mar 16;315(5818):1576-9
pubmed: 17322030
Cancer Res. 2004 Sep 15;64(18):6603-9
pubmed: 15374974
Leukemia. 2006 Dec;20(12):2190-2
pubmed: 17024113
Nutrients. 2016 May 20;8(5):
pubmed: 27213442
Mol Cell Biochem. 2013 Feb;374(1-2):173-80
pubmed: 23229232
Oncogene. 1996 Dec 5;13(11):2439-46
pubmed: 8957086
Nat Cell Biol. 2008 Aug;10(8):987-93
pubmed: 18604195
Appl Health Econ Health Policy. 2019 Dec;17(6):827-839
pubmed: 31392669
Exp Hematol. 2007 Nov;35(11):1708-18
pubmed: 17976522
Cold Spring Harb Symp Quant Biol. 1993;58:73-81
pubmed: 7956090
Cancer Res. 2006 Mar 1;66(5):2536-43
pubmed: 16510570
FEBS Lett. 2013 Aug 2;587(15):2467-73
pubmed: 23796420
Pediatr Blood Cancer. 2013 Jun;60(6):957-63
pubmed: 23255467
Cancer Res. 2008 Dec 15;68(24):10121-7
pubmed: 19074878
Biochim Biophys Acta. 2001 May 28;1519(1-2):13-29
pubmed: 11406267
Blood. 2011 Jul 28;118(4):1069-76
pubmed: 21596848
Genes Dev. 2007 May 1;21(9):1005-9
pubmed: 17473167
Cell Physiol Biochem. 2014;33(5):1329-39
pubmed: 24803022
Cell Biol Int. 2013 Oct;37(10):1114-21
pubmed: 23716467
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8
pubmed: 22623533
Nature. 1973 Jun 1;243(5405):290-3
pubmed: 4126434
Mol Cancer. 2007 Jan 14;6:5
pubmed: 17222355
Breast Cancer Res Treat. 2002 Feb;71(3):181-91
pubmed: 12002338
Leuk Lymphoma. 2007 Oct;48(10):2008-13
pubmed: 17917968
Leuk Lymphoma. 2006 Sep;47(9):1956-9
pubmed: 17065012
Leuk Lymphoma. 2011 Oct;52(10):1999-2006
pubmed: 21728742
Oncol Rep. 2016 Jul;36(1):376-82
pubmed: 27175617
Cell. 2011 Nov 23;147(5):1066-79
pubmed: 22118463
Medicine (Baltimore). 2017 Sep;96(39):e7952
pubmed: 28953617
Leuk Lymphoma. 2013 Nov;54(11):2565-7
pubmed: 23472968
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4256-61
pubmed: 10759549
Nat Genet. 2007 May;39(5):673-7
pubmed: 17401365
Blood. 2011 Aug 18;118(7):1723-35
pubmed: 21653328
Mol Cell Biol. 2003 Apr;23(7):2225-38
pubmed: 12640109
RNA. 2008 Aug;14(8):1539-49
pubmed: 18566191
Anal Biochem. 2008 Mar 1;374(1):7-15
pubmed: 18023407
Leukemia. 2008 Oct;22(10):1828-40
pubmed: 18769448
Cell. 2005 Mar 11;120(5):635-47
pubmed: 15766527
Gene. 2001 Oct 17;277(1-2):63-81
pubmed: 11602345
Oncogene. 2008 Sep 18;27(41):5497-510
pubmed: 18794884
J Clin Invest. 2012 Oct;122(10):3398-406
pubmed: 23023710
J Exp Med. 2012 Mar 12;209(3):445-54
pubmed: 22351929
Mol Cancer Ther. 2008 Jul;7(7):2090-5
pubmed: 18645019
Cancer Sci. 2012 Mar;103(3):439-47
pubmed: 22106824
EMBO J. 1993 Jan;12(1):115-26
pubmed: 8381347
Mol Cell Biol. 2000 Aug;20(15):5490-502
pubmed: 10891489
Mod Pathol. 2010 Jan;23(1):98-104
pubmed: 19820691
Genes Chromosomes Cancer. 1999 Aug;25(4):316-22
pubmed: 10398424
Biochim Biophys Acta. 2005 Dec 30;1754(1-2):3-13
pubmed: 16172030
Exp Hematol. 2007 Apr;35(4):618-26
pubmed: 17379072
Mol Cell Biol. 1996 Aug;16(8):4544-54
pubmed: 8754855
Blood. 2011 Dec 8;118(24):6392-8
pubmed: 21860020
Nature. 2000 Nov 2;408(6808):86-9
pubmed: 11081512
Blood. 2014 Oct 2;124(14):2203-12
pubmed: 25150295
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1526-31
pubmed: 9990057
Cancer Cell. 2005 Apr;7(4):387-97
pubmed: 15837627
Br J Cancer. 2018 Feb 6;118(3):405-415
pubmed: 29384529
Blood. 2010 Jun 3;115(22):4356-66
pubmed: 20228274
Stem Cells Dev. 2014 Jul 1;23(13):1452-63
pubmed: 24617339
J Transl Med. 2017 Aug 2;15(1):169
pubmed: 28768505
PLoS One. 2014 Oct 21;9(10):e110850
pubmed: 25335083
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9920-5
pubmed: 23716660
Mini Rev Med Chem. 2011 Jun;11(6):544-52
pubmed: 21561401
Chem Biol. 2000 Oct;7(10):805-12
pubmed: 11033083
Nature. 1986 Dec 11-17;324(6097):585-9
pubmed: 3491327
Int J Oncol. 2019 Oct;55(4):775-788
pubmed: 31432151
Haematologica. 2013 Mar;98(3):399-403
pubmed: 22801965
Dig Dis Sci. 2013 Mar;58(3):724-33
pubmed: 23135750
Blood. 2002 Jan 1;99(1):121-9
pubmed: 11756161
Oncogene. 1998 Jul 30;17(4):413-8
pubmed: 9696033
Nature. 1995 Aug 31;376(6543):771-4
pubmed: 7651535
J Natl Cancer Inst. 1960 Jul;25:85-109
pubmed: 14427847
Nucleic Acids Res. 1999 May 15;27(10):2135-44
pubmed: 10219086
PLoS One. 2012;7(1):e30034
pubmed: 22276142
Blood Adv. 2019 Jan 8;3(1):72-82
pubmed: 30622145
Leuk Lymphoma. 2013 Aug;54(8):1762-8
pubmed: 23311322
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7970-5
pubmed: 11427729
Eur J Cancer. 2007 Jul;43(10):1529-44
pubmed: 17531469
Nature. 2002 Jan 24;415(6870):436-42
pubmed: 11807556
J Biol Chem. 2010 Mar 26;285(13):9636-41
pubmed: 20118233
Mol Cell. 2008 Oct 24;32(2):276-84
pubmed: 18951094
Cancer Res. 1999 Jan 1;59(1):19-23
pubmed: 9892177
Cancer Res. 2004 May 15;64(10):3371-5
pubmed: 15150086
Trends Mol Med. 2008 Sep;14(9):400-9
pubmed: 18674967
EMBO Mol Med. 2013 Feb;5(2):264-79
pubmed: 23307470
Blood. 2013 Aug 8;122(6):872-84
pubmed: 23803709
J Biol Chem. 2013 Jun 7;288(23):16348-60
pubmed: 23625920
Haematologica. 2008 Jul;93(7):1009-16
pubmed: 18508790
Leuk Lymphoma. 2016 Nov;57(11):2681-4
pubmed: 26952843
Cell. 2008 Oct 17;135(2):227-39
pubmed: 18957199
J Cancer Res Clin Oncol. 2016 Feb;142(2):389-99
pubmed: 26319392
Int J Colorectal Dis. 2009 Nov;24(11):1281-6
pubmed: 19609535
Cancer Res. 2007 May 1;67(9):3998-4004
pubmed: 17483309
Biochemistry. 1996 Apr 16;35(15):5063-74
pubmed: 8664299
Fukushima J Med Sci. 2012;58(2):91-100
pubmed: 23237864
Cell Stem Cell. 2009 Feb 6;4(2):129-40
pubmed: 19200802
Nucleic Acids Res. 1993 Sep 11;21(18):4259-67
pubmed: 8414980
Blood Adv. 2019 Feb 12;3(3):320-332
pubmed: 30709863
Oncogene. 2005 May 12;24(21):3427-35
pubmed: 15735694
Leukemia. 2014 May;28(5):1022-32
pubmed: 24270738
Nature. 2010 Sep 16;467(7313):318-22
pubmed: 20844535
Lancet. 2008 Mar 22;371(9617):1030-43
pubmed: 18358930
J Biol Chem. 1995 Mar 3;270(9):4355-60
pubmed: 7876198
J Biol Chem. 2003 Oct 24;278(43):42106-14
pubmed: 12907668
Mol Cell. 2007 Feb 9;25(3):473-81
pubmed: 17289593
Leuk Lymphoma. 1997 Aug;26(5-6):603-7
pubmed: 9389367
Cell. 2008 Dec 12;135(6):1013-6
pubmed: 19070572
Front Med (Lausanne). 2015 Mar 25;2:15
pubmed: 25859543
Genes (Basel). 2019 Dec 09;10(12):
pubmed: 31835432
Nature. 2005 Jun 9;435(7043):834-8
pubmed: 15944708
Blood. 1998 Oct 1;92(7):2322-33
pubmed: 9746770
N Engl J Med. 2015 Sep 17;373(12):1136-52
pubmed: 26376137
PLoS One. 2016 Nov 18;11(11):e0166928
pubmed: 27861570
Nat Rev Cancer. 2011 Jun 24;11(7):503-11
pubmed: 21701512
Blood Rev. 2004 Jun;18(2):115-36
pubmed: 15010150
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):48-54
pubmed: 20123067
Haematologica. 2014 Dec;99(12):e257-9
pubmed: 25150259
Nat Genet. 1995 Aug;10(4):436-44
pubmed: 7670494
Blood. 2008 Sep 15;112(6):2183-9
pubmed: 18779403
Oncotarget. 2017 Jan 31;8(5):8420-8435
pubmed: 28039479
Stem Cells. 2007 Jan;25(1):165-73
pubmed: 16990584
N Engl J Med. 2003 Mar 13;348(11):994-1004
pubmed: 12637609
Cancer Genet Cytogenet. 2007 Jul 1;176(1):80-8
pubmed: 17574970
Genes Dev. 2007 May 1;21(9):1025-30
pubmed: 17437991
Br J Haematol. 2012 Jun;157(6):769-71
pubmed: 22404713
J Thromb Haemost. 2013 Sep;11(9):1730-41
pubmed: 23782903
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13966-71
pubmed: 11717454
Cancer Res. 2010 Jan 15;70(2):436-9
pubmed: 20068164
Adv Anat Pathol. 1999 Sep;6(5):237-46
pubmed: 10472377
Blood Adv. 2017 Jun 14;1(15):1001-1015
pubmed: 29296743
Genomics. 1996 Aug 15;36(1):118-29
pubmed: 8812423
Haematologica. 2006 Jun;91(6):856-7
pubmed: 16704965
FEBS Lett. 2007 Jul 24;581(18):3533-7
pubmed: 17624332
Nat Genet. 2008 May;40(5):499-507
pubmed: 18443585
Blood. 2017 Jan 26;129(4):424-447
pubmed: 27895058
Curr Opin Hematol. 1996 Mar;3(2):101-10
pubmed: 9372059
Leukemia. 1999 Jun;13(6):884-90
pubmed: 10360377
Cancer Genet Cytogenet. 2000 May;119(1):70-3
pubmed: 10812175
Biomed Pharmacother. 2018 Dec;108:43-49
pubmed: 30216798
Cell. 1992 Nov 27;71(5):777-89
pubmed: 1330326
Int J Mol Sci. 2020 Jan 22;21(3):
pubmed: 31979076
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19069-74
pubmed: 16354839
Cancer Res. 2008 Apr 15;68(8):2587-91
pubmed: 18413726
Cancers (Basel). 2020 Jan 11;12(1):
pubmed: 31940809
Blood Cells Mol Dis. 2013 Mar;50(3):190-5
pubmed: 23265742
BMC Genomics. 2011 Nov 04;12:549
pubmed: 22053823
Blood. 2008 Sep 15;112(6):2429-38
pubmed: 18612101
PLoS One. 2012;7(2):e32584
pubmed: 22393418
Blood. 2009 Mar 12;113(11):2375-85
pubmed: 19056693
Blood. 2016 Feb 11;127(6):663
pubmed: 26869302
Annu Rev Med. 2016;67:73-89
pubmed: 26768237
Blood. 2009 Jul 30;114(5):937-51
pubmed: 19357394
Science. 1999 Oct 15;286(5439):531-7
pubmed: 10521349
Cell. 1998 Jan 9;92(1):5-8
pubmed: 9489694
J Biol Chem. 1998 Aug 7;273(32):20015-20
pubmed: 9685339
Curr Genomics. 2007 Aug;8(5):271-306
pubmed: 19384426
Blood. 2002 Jul 1;100(1):22-8
pubmed: 12070003
Cancer Genet Cytogenet. 2007 Sep;177(2):115-9
pubmed: 17854665
PLoS One. 2012;7(11):e48533
pubmed: 23166588
Nat Rev Cancer. 2007 Dec;7(12):899-910
pubmed: 18004397
Cancer Res. 2000 Aug 1;60(15):4256-61
pubmed: 10945639
Blood. 2016 Jun 30;127(26):3410-23
pubmed: 27081096
Science. 1994 May 20;264(5162):1100-1
pubmed: 8178167
Nat Cell Biol. 2013 Aug;15(8):916-25
pubmed: 23811688
Genes Chromosomes Cancer. 2004 Jan;39(1):82-7
pubmed: 14603445
FASEB J. 2003 Aug;17(11):1496-8
pubmed: 12824305
Leukemia. 2013 Feb;27(2):389-97
pubmed: 22918121
Leuk Lymphoma. 2007 Aug;48(8):1587-99
pubmed: 17701591
Am J Pathol. 1996 Sep;149(3):775-9
pubmed: 8780382
Br J Haematol. 2015 Dec;171(5):818-29
pubmed: 26403224
Cell. 1995 Dec 29;83(7):1091-100
pubmed: 8548797
Mol Cell Biol. 2018 Jun 28;38(14):
pubmed: 29712758
Leukemia. 2005 Feb;19(2):245-52
pubmed: 15618963
Cancer Genet Cytogenet. 1997 Jun;95(2):198-205
pubmed: 9169041
PLoS One. 2015 May 01;10(5):e0125414
pubmed: 25933067
Leuk Lymphoma. 2018 Nov;59(11):2639-2649
pubmed: 29569972
Sci Rep. 2015 Oct 26;5:15646
pubmed: 26497577
Oncotarget. 2017 Sep 13;8(47):81794-81802
pubmed: 29137222
Mol Cell Biol. 1997 Jul;17(7):3527-35
pubmed: 9199288
Int J Mol Sci. 2019 Jun 15;20(12):
pubmed: 31208040
Haematologica. 2017 Mar;102(3):509-518
pubmed: 28057739
Oncogene. 2012 Feb 16;31(7):918-28
pubmed: 21743487
Genes Chromosomes Cancer. 1999 Oct;26(2):125-33
pubmed: 10469450
Mol Cell Biol. 1995 Mar;15(3):1545-53
pubmed: 7862147
Chromosoma. 1992 Oct;101(10):602-8
pubmed: 1385053
Biochem Biophys Res Commun. 1998 Jan 14;242(2):452-6
pubmed: 9446816
Crit Rev Food Sci Nutr. 2018 Apr 13;58(6):924-941
pubmed: 27645804
Diagn Pathol. 2016 Oct 10;11(1):96
pubmed: 27724982
Blood. 2006 Dec 15;108(13):4232-6
pubmed: 16940417
Science. 2007 Dec 21;318(5858):1917-20
pubmed: 18029452
Cancer Genet. 2012 Jun;205(6):295-303
pubmed: 22749035
Leuk Lymphoma. 2014 May;55(5):1194-7
pubmed: 23829279
Mol Cancer Res. 2008 May;6(5):743-50
pubmed: 18505920
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12223-7
pubmed: 7527557
Br J Haematol. 2012 Feb;156(3):383-7
pubmed: 22017592
Curr Opin Genet Dev. 2003 Feb;13(1):77-83
pubmed: 12573439
Mol Cell Biol. 2001 Apr;21(7):2485-95
pubmed: 11259597
N Engl J Med. 2005 Apr 28;352(17):1779-90
pubmed: 15858187
Genes Chromosomes Cancer. 2005 Jan;42(1):87-94
pubmed: 15495192
Leuk Lymphoma. 2007 Oct;48(10):1898-9
pubmed: 17917958
Ann Hematol. 2017 Apr;96(4):567-574
pubmed: 28054140
Sci Rep. 2017 Nov 21;7(1):15973
pubmed: 29162914