Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions.
hypoxia
lung cancer
renin-angiotensin
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
16
04
2020
revised:
24
05
2020
accepted:
01
06
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
7
6
2020
Statut:
epublish
Résumé
The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
Identifiants
pubmed: 32503281
pii: cancers12061457
doi: 10.3390/cancers12061457
pmc: PMC7352181
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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