Neural Correlates of Gender Face Perception in Transgender People.
gender dysphoria
gender face perception
gender incongruence
transmen
transwomen
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
11
04
2020
revised:
26
05
2020
accepted:
01
06
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
7
6
2020
Statut:
epublish
Résumé
To date, MRI studies focused on brain sexual dimorphism have not explored the presence of specific neural patterns in gender dysphoria (GD) using gender discrimination tasks. Considering the central role of body image in GD, the present study aims to evaluate brain activation patterns with 3T-scanner functional MRI (fMRI) during gender face discrimination task in a sample of 20 hormone-naïve transgender and 20 cisgender individuals. Additionally, participants were asked to complete psychometric measures. The between-group analysis of average blood oxygenation level dependent (BOLD) activations of female vs. male face contrast showed a significant positive cluster in the bilateral precuneus in transmen when compared to the ciswomen. In addition. the transwomen group compared to the cismen showed higher activations also in the precuneus, as well as in the posterior cingulate gyrus, the angular gyrus and the lateral occipital cortices. Moreover, the activation of precuneus, angular gyrus, lateral occipital cortices and posterior cingulate gyrus was significantly associated with higher levels of body uneasiness. These results show for the first time the existence of a possible specific GD-neural pattern. However, it remains unclear if the differences in brain phenotype of transgender people may be the result of a sex-atypical neural development or of a lifelong experience of gender non-conformity.
Identifiants
pubmed: 32503300
pii: jcm9061731
doi: 10.3390/jcm9061731
pmc: PMC7356844
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Curr Biol. 2007 Sep 18;17(18):1568-73
pubmed: 17764942
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9403-8
pubmed: 18559854
Cortex. 2011 Mar;47(3):367-76
pubmed: 20444445
Brain Imaging Behav. 2017 Aug;11(4):964-976
pubmed: 27444730
Neuropsychologia. 2006;44(4):594-609
pubmed: 16125741
Psychoneuroendocrinology. 2016 Nov;73:91-98
pubmed: 27479654
Neuroimage. 2010 Oct 1;52(4):1559-73
pubmed: 20457261
J Neurosci. 2014 Nov 12;34(46):15466-75
pubmed: 25392513
J Sex Med. 2013 Apr;10(4):1012-23
pubmed: 23347389
PLoS One. 2013 Dec 31;8(12):e83947
pubmed: 24391851
Neuroimage. 2020 May 1;211:116613
pubmed: 32057995
J Sex Med. 2013 Aug;10(8):1969-77
pubmed: 23433223
J Cogn Neurosci. 2004 Dec;16(10):1746-72
pubmed: 15701226
Trends Cogn Sci. 2000 Jul;4(7):267-278
pubmed: 10859571
Science. 2007 Jan 19;315(5810):393-5
pubmed: 17234951
Brain. 2003 Nov;126(Pt 11):2381-95
pubmed: 12876150
Vision Res. 2012 Jun 15;63:69-80
pubmed: 22595743
J Psychiatr Res. 2011 Feb;45(2):199-204
pubmed: 20562024
Trends Neurosci. 2015 May;38(5):261-3
pubmed: 25841798
Arch Sex Behav. 2009 Jun;38(3):364-77
pubmed: 19030979
J Psychiatry Neurosci. 2016 Oct;41(6):395-404
pubmed: 27070350
Neuroimage. 2009 Jul 15;46(4):904-7
pubmed: 19341803
J Endocrinol Invest. 2017 Mar;40(3):263-273
pubmed: 27639401
Cereb Cortex. 2013 Dec;23(12):2855-62
pubmed: 22941717
Cereb Cortex. 2020 May 14;30(5):2897-2909
pubmed: 31813993
Eat Weight Disord. 2006 Mar;11(1):1-13
pubmed: 16801740
J Clin Endocrinol Metab. 2016 Nov;101(11):4260-4269
pubmed: 27700538
Arch Sex Behav. 2016 Apr;45(3):525-36
pubmed: 26292839
J Neuropsychol. 2019 Sep;13(3):503-508
pubmed: 30156753
Cereb Cortex. 2010 Apr;20(4):813-25
pubmed: 19620621
J Neurophysiol. 2009 May;101(5):2581-600
pubmed: 19225169
Curr Opin Neurobiol. 2003 Aug;13(4):500-5
pubmed: 12965300
Brain. 2006 Mar;129(Pt 3):564-83
pubmed: 16399806
Brain Behav. 2017 Apr 05;7(5):e00691
pubmed: 28523232
Sci Rep. 2018 Jan 15;8(1):736
pubmed: 29335438
Cereb Cortex. 2020 May 14;30(5):2755-2765
pubmed: 31999324
Trends Cogn Sci. 2011 Nov;15(11):527-36
pubmed: 22001867
Neuroendocrinology. 2017;105(2):123-130
pubmed: 27490457
J Sex Med. 2020 Apr;17(4):570-584
pubmed: 32111534
Neuroimage. 2007 Jul 1;36(3):511-21
pubmed: 17499520
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Hum Brain Mapp. 2017 May;38(5):2553-2565
pubmed: 28218433
Neurosci Biobehav Rev. 2005 Apr;29(2):353-84
pubmed: 15811504
Eur Psychiatry. 2012 Nov;27(8):591-7
pubmed: 21334861
J Sex Med. 2015 Dec;12(12):2413-24
pubmed: 26612786
Psychoneuroendocrinology. 2015 May;55:59-71
pubmed: 25720349
Cereb Cortex. 2018 May 1;28(5):1582-1596
pubmed: 28334217
Int J Mol Sci. 2020 Mar 19;21(6):
pubmed: 32204531
Biol Psychiatry. 2008 Feb 1;63(3):332-7
pubmed: 17888409
Nat Neurosci. 2005 Jan;8(1):107-13
pubmed: 15592463
Cereb Cortex. 2017 Feb 1;27(2):998-1010
pubmed: 26637450
Neuron. 2004 Dec 2;44(5):889-98
pubmed: 15572118
Cereb Cortex. 2019 May 1;29(5):2084-2101
pubmed: 30084980
J Sex Med. 2010 May;7(5):1858-67
pubmed: 19751389
Int Rev Psychiatry. 2016;28(1):120-8
pubmed: 26766406
J Sex Med. 2014 Mar;11(3):709-19
pubmed: 24330520
J Neurosci. 2016 Jun 1;36(22):6069-82
pubmed: 27251627
Neurology. 2002 Jan 8;58(1):71-8
pubmed: 11781408
Prog Brain Res. 2005;150:205-17
pubmed: 16186025
J Psychiatr Res. 2011 Jul;45(7):949-54
pubmed: 21195418
Cortex. 2016 Oct;83:86-100
pubmed: 27498040
Sci Rep. 2018 Jan 12;8(1):673
pubmed: 29330483
Front Neuroendocrinol. 2011 Apr;32(2):214-26
pubmed: 21334362