The TRPM7 Channel in the Nervous and Cardiovascular Systems.
Calcium
/ metabolism
Cardiotonic Agents
/ therapeutic use
Cardiovascular System
/ drug effects
Cations, Divalent
Gene Expression
Homeostasis
/ drug effects
Humans
Ion Transport
/ drug effects
Magnesium
/ metabolism
Myocytes, Cardiac
/ drug effects
Nervous System
/ drug effects
Neurons
/ drug effects
Neuroprotective Agents
/ therapeutic use
Phosphorylation
/ drug effects
Protein Serine-Threonine Kinases
/ chemistry
Stroke
/ genetics
Synaptic Transmission
TRPM Cation Channels
/ chemistry
TRPM7
cardiovascular system
ion channel
kinase
nervous system
stroke
Journal
Current protein & peptide science
ISSN: 1875-5550
Titre abrégé: Curr Protein Pept Sci
Pays: United Arab Emirates
ID NLM: 100960529
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
01
2020
revised:
27
04
2020
accepted:
28
05
2020
pubmed:
7
6
2020
medline:
26
5
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. Interestingly, at a higher level, TRPM7 participates in several biological processes in the nervous and cardiovascular systems, in which excitatory responses in neurons and cardiomyocytes are critical for their function. Here, we review the roles of TRPM7 in cells involved in the nervous and cardiovascular systems and discuss its potential as a future therapeutic target.
Identifiants
pubmed: 32503408
pii: CPPS-EPUB-107140
doi: 10.2174/1389203721666200605170938
doi:
Substances chimiques
Cardiotonic Agents
0
Cations, Divalent
0
Neuroprotective Agents
0
TRPM Cation Channels
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
TRPM7 protein, human
EC 2.7.11.1
Magnesium
I38ZP9992A
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
985-992Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.