Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders.
Dendritic cells
Effector T cells (Teffs)
Immune transformation
Microglia
Neurodegenerative disorders
Regulatory T cells (Tregs)
Journal
Molecular neurodegeneration
ISSN: 1750-1326
Titre abrégé: Mol Neurodegener
Pays: England
ID NLM: 101266600
Informations de publication
Date de publication:
05 06 2020
05 06 2020
Historique:
received:
17
01
2020
accepted:
13
04
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
2
7
2021
Statut:
epublish
Résumé
Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage of the aggregated protein antigens into cervical lymph nodes serving to amplify effector immune responses. Both preclinical and clinical studies demonstrate transformation of this altered immunity for therapeutic gain. We posit that the signs and symptoms of common neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke can be attenuated by boosting Treg activities.
Identifiants
pubmed: 32503641
doi: 10.1186/s13024-020-00375-7
pii: 10.1186/s13024-020-00375-7
pmc: PMC7275301
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Subventions
Organisme : NIMH NIH HHS
ID : P30 MH062261
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043540
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034239
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115860
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA028555
Pays : United States
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