Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke-evaluating the impact of therapeutic time points on prognostic outcomes.


Journal

Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581

Informations de publication

Date de publication:
05 06 2020
Historique:
received: 07 02 2020
accepted: 20 05 2020
revised: 06 05 2020
entrez: 7 6 2020
pubmed: 7 6 2020
medline: 22 6 2021
Statut: epublish

Résumé

This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute ischemic stroke (IS). Adult male SD rats (n = 70) were equally categorized into group 1 (sham-operated control), group 2 (IS), group 3 (IS+EPCs/1.2 × 10 Early EPC administration provided better benefits on improving functional/image/molecular-cellular outcomes after acute IS in rat.

Sections du résumé

BACKGROUND
This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute ischemic stroke (IS).
METHODS AND RESULTS
Adult male SD rats (n = 70) were equally categorized into group 1 (sham-operated control), group 2 (IS), group 3 (IS+EPCs/1.2 × 10
CONCLUSION
Early EPC administration provided better benefits on improving functional/image/molecular-cellular outcomes after acute IS in rat.

Identifiants

pubmed: 32503671
doi: 10.1186/s13287-020-01739-y
pii: 10.1186/s13287-020-01739-y
pmc: PMC7275327
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

219

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Auteurs

Kun-Chen Lin (KC)

Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Han-Tan Chai (HT)

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.

Kuan-Hung Chen (KH)

Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Pei-Hsun Sung (PH)

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

John Y Chiang (JY)

Department of Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung, Taiwan.

Pei-Lin Shao (PL)

Department of Nursing, Asia University, Taichung, Taiwan.

Chi-Ruei Huang (CR)

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Yi-Chen Li (YC)

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.

Sheung-Fat Ko (SF)

Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Hon-Kan Yip (HK)

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan. han.gung@msa.hinet.net.
Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. han.gung@msa.hinet.net.
Department of Nursing, Asia University, Taichung, Taiwan. han.gung@msa.hinet.net.
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. han.gung@msa.hinet.net.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. han.gung@msa.hinet.net.
Division of Cardiology, Department of Internal Medicine, Xiamen Chang Gung Hospital, Xiamen, Fujian, China. han.gung@msa.hinet.net.

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Classifications MeSH