SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.
IBD
IBD - genetics
epithelial differentiation
gut inflammation
intestinal epithelium
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
06
04
2020
revised:
05
05
2020
accepted:
12
05
2020
pubmed:
7
6
2020
medline:
5
10
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD. We investigated mice with constitutive and inducible intestinal epithelial deletion of Deletion of intestinal epithelial SETDB1 plays an essential role in intestinal epithelial homeostasis. Future work is required to investigate whether rare variants in
Identifiants
pubmed: 32503845
pii: gutjnl-2020-321339
doi: 10.1136/gutjnl-2020-321339
pmc: PMC7873423
doi:
Substances chimiques
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
SETDB1 protein, human
EC 2.1.1.43
SETDB1 protein, mouse
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-498Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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