Anomalous expression of miR-103 in polycystic ovary syndrome influenced by hormonal, and metabolic variables.
BMI
PCOS
miR-103
microRNAs
Journal
Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
04
2020
revised:
21
05
2020
accepted:
01
06
2020
pubmed:
7
6
2020
medline:
16
12
2020
entrez:
7
6
2020
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS), a common endocrine disorder in reproductive-aged women, is correlated with obesity and insulin resistance (IR), androgens excess, chronic anovulation, and infertility. MicroRNAs (miRNAs) are small, single-stranded, noncoding RNA molecules that participate in inflammation, reproduction and metabolism, may contribute to PCOS. Current study aiming to manifest the correlation of body mass index (BMI) and testosterone (T) with miR-103 expression before and after fat loss. 46 controls (N = 23 with BMI < 24 kg/m miR-103 was correlated with BMI rather than testosterone (T), and there was a significant difference between the non-obese and obese groups in miR-103 expression. Compared to before fat loss, miR-103 expression showed a slight downward trend. Serum miR-103 differentially expressed between controls and PCOS subjects, miR-103 was positively correlated with BMI. There was significant difference between the non-obese and obese groups in miR-103 expression.
Sections du résumé
BACKGROUND
Polycystic ovary syndrome (PCOS), a common endocrine disorder in reproductive-aged women, is correlated with obesity and insulin resistance (IR), androgens excess, chronic anovulation, and infertility. MicroRNAs (miRNAs) are small, single-stranded, noncoding RNA molecules that participate in inflammation, reproduction and metabolism, may contribute to PCOS. Current study aiming to manifest the correlation of body mass index (BMI) and testosterone (T) with miR-103 expression before and after fat loss.
METHODS
46 controls (N = 23 with BMI < 24 kg/m
RESULTS
miR-103 was correlated with BMI rather than testosterone (T), and there was a significant difference between the non-obese and obese groups in miR-103 expression. Compared to before fat loss, miR-103 expression showed a slight downward trend.
CONCLUSIONS
Serum miR-103 differentially expressed between controls and PCOS subjects, miR-103 was positively correlated with BMI. There was significant difference between the non-obese and obese groups in miR-103 expression.
Identifiants
pubmed: 32504622
pii: S0014-4800(20)30438-X
doi: 10.1016/j.yexmp.2020.104482
pii:
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
MIRN103 microRNA, human
0
MicroRNAs
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104482Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.