Opioid receptors beyond pain control: The role in cancer pathology and the debated importance of their pharmacological modulation.
Angiogenesis
Cancer
FENTANYL: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Immunosuppression
METHYLNALTREXONE: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one
MORPHINE: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Metastasis
NALOXONE: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
NALTREXONE: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Opioid receptors
Opioids
TAPENTADOL: 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol
TRAMADOL: (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
05
12
2019
revised:
24
03
2020
accepted:
15
05
2020
pubmed:
7
6
2020
medline:
6
7
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
Stimulation of opioid receptors is widely used for relieving cancer pain in patients with advanced cancer. The expression of tissue opioid receptors varies depending on the types of cancer and it is regulated by several factors. This review provides a focused overview of the current evidence for the role of opioid receptors in modulating cancer progression, a discussion of the proposed underlying mechanisms and the pharmacological activity of opioid agonists and antagonists. Conflicting evidence from preclinical and clinical studies suggests the possible involvement of opioid receptor agonists in both the development and suppression of human cancer. Some retrospective clinical studies also show a possible detrimental effect on long-term patient outcomes. Among the opioid receptor agonists, morphine has been extensively studied in various cancer types. Moreover, various pathological processes of human cancer are affected by opioid receptor agonists, such as tumour growth, angiogenesis and immunosuppression. These findings highlight the functional value of opioid receptors in human cancer, and a potential double role of opioid receptor agonists and antagonists in human cancer treatment.
Identifiants
pubmed: 32504831
pii: S1043-6618(20)31246-9
doi: 10.1016/j.phrs.2020.104938
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Antineoplastic Agents
0
Narcotic Antagonists
0
Receptors, Opioid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104938Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.