Could autism spectrum disorders be a risk factor for COVID-19?
Autism Spectrum Disorder
COVID-19
Coronavirus
Risk Factor
SARS-CoV-2
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
29
04
2020
revised:
18
05
2020
accepted:
27
05
2020
pubmed:
7
6
2020
medline:
23
12
2020
entrez:
7
6
2020
Statut:
ppublish
Résumé
The coronavirus SARS-CoV-2 pandemia is infecting millions of people and some studies relate conditions that might increase the risk of developing a fatal course for the disease, such as diabetes, cardiovascular diseases and obesity. In COVID-19 physiopathology, one of the main inflammation mechanisms is the "cytokine storm", causing a pro-inflammatory state, related to cardiac and pulmonary damage. There is also a less effective role of lymphocyte B and T in the humoral immunity due to the reduction of their proliferative response. The physiopathology of ASD (Autism Spectrum Disorder) involves several modifications at the genetic and at the immune level, such as the increase of inflammatory cytokines and abnormal immune response in several levels. We hypothesize that ASD could be a risk-factor as the other conditions are.
Identifiants
pubmed: 32505067
pii: S0306-9877(20)31071-9
doi: 10.1016/j.mehy.2020.109899
pmc: PMC7261065
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109899Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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