Relation of Copeptin with Diabetic and Renal Function Markers Among Patients with Diabetes Mellitus Progressing Towards Diabetic Nephropathy.
Adolescent
Adult
Aged
Biomarkers
/ blood
Diabetes Mellitus, Type 2
/ blood
Diabetic Nephropathies
/ blood
Female
Glycopeptides
/ adverse effects
Humans
Kidney
/ pathology
Kidney Function Tests
/ methods
Male
Middle Aged
Neurophysins
/ metabolism
Prognosis
Protein Precursors
/ metabolism
Vasopressins
/ metabolism
Young Adult
Copeptin
Diabetes mellitus
Diabetic nephropathy
Glomerular filtration rate
Pre diabetes
Vasopressin
Journal
Archives of medical research
ISSN: 1873-5487
Titre abrégé: Arch Med Res
Pays: United States
ID NLM: 9312706
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
10
03
2020
revised:
10
05
2020
accepted:
21
05
2020
pubmed:
9
6
2020
medline:
18
11
2020
entrez:
8
6
2020
Statut:
ppublish
Résumé
Arginine vasopressin (AVP) plays an important role in the pathophysiology of Diabetes Mellitus (DM) and its related complications like diabetic nephropathy. Copeptin is considered as a reliable surrogate biomarker of AVP. If raised levels of copeptin in diabetic patients are detected earlier, prognosis of DM can be improved by timely modulating the treatment strategy. The study is therefore planned to assess copeptin levels in different groups of DM and in healthy controls to suggest a better and reliable biomarker for progressive stages of DM. Subjects were recruited as controls, pre diabetes, DM without nephropathy and diabetic nephropathy. Serum copeptin levels were measured by ELISA. While, Blood Urea Nitrogen (BUN), creatinine, Glycosylated Hemoglobin (HbA1c) and spot urinary albumin creatinine ratio (UACR) were done using spectrophotometry. Statistical analysis was done using ANOVA and Pearson's correlation tests on SPSS. The average copeptin levels were 215.096 pg/mL. Copeptin levels were significantly elevated in subjects with positive family history of DM (p = 0.025), levels were also raised in pre diabetes kpatients (252.85 pg/mL) as compared to other groups. Copeptin levels were also correlated with HbA1c r = 0.171 (p = 0.101), BUN r = 0.244 (p = 0.007), creatinine r = 0.215 (p = 0.018), UACR r = 0.375 (p = <0.001) and GFR r = 0.215 (p = <0.019). The significant correlation of copeptin with diabetic and renal biomarkers, along with its positive association with family history of DM support its' role as an early and reliable biomarker of DM and its associated nephropathy.
Sections du résumé
BACKGROUND
Arginine vasopressin (AVP) plays an important role in the pathophysiology of Diabetes Mellitus (DM) and its related complications like diabetic nephropathy. Copeptin is considered as a reliable surrogate biomarker of AVP. If raised levels of copeptin in diabetic patients are detected earlier, prognosis of DM can be improved by timely modulating the treatment strategy.
AIMS OF THE STUDY
The study is therefore planned to assess copeptin levels in different groups of DM and in healthy controls to suggest a better and reliable biomarker for progressive stages of DM.
METHODS
Subjects were recruited as controls, pre diabetes, DM without nephropathy and diabetic nephropathy. Serum copeptin levels were measured by ELISA. While, Blood Urea Nitrogen (BUN), creatinine, Glycosylated Hemoglobin (HbA1c) and spot urinary albumin creatinine ratio (UACR) were done using spectrophotometry. Statistical analysis was done using ANOVA and Pearson's correlation tests on SPSS.
RESULTS
The average copeptin levels were 215.096 pg/mL. Copeptin levels were significantly elevated in subjects with positive family history of DM (p = 0.025), levels were also raised in pre diabetes kpatients (252.85 pg/mL) as compared to other groups. Copeptin levels were also correlated with HbA1c r = 0.171 (p = 0.101), BUN r = 0.244 (p = 0.007), creatinine r = 0.215 (p = 0.018), UACR r = 0.375 (p = <0.001) and GFR r = 0.215 (p = <0.019).
CONCLUSION
The significant correlation of copeptin with diabetic and renal biomarkers, along with its positive association with family history of DM support its' role as an early and reliable biomarker of DM and its associated nephropathy.
Identifiants
pubmed: 32505416
pii: S0188-4409(20)30306-4
doi: 10.1016/j.arcmed.2020.05.018
pii:
doi:
Substances chimiques
AVP protein, human
0
Biomarkers
0
Glycopeptides
0
Neurophysins
0
Protein Precursors
0
copeptins
0
Vasopressins
11000-17-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
548-555Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 IMSS. Published by Elsevier Inc. All rights reserved.